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O blood usage trends in the pediatric population 2015-2019: A multi-institutional analysis

K Annen1,2, S Andani2, G Bosma3

  • 1Children's Hospital Colorado, Aurora, Colorado, USA.

Transfusion
|March 28, 2025
PubMed

Insights

Pediatric transfusions often use group O red blood cells even for non-O patients. This study identified key patient groups, like those with cardiovascular disorders and sickle cell anemia, receiving group O blood, offering insights for blood supply management.

Area of Science:

  • Transfusion Medicine
  • Pediatric Hematology
  • Blood Banking

Background:

  • Limited 2019 AABB recommendations on group O red blood cell use in pediatrics.
  • Eight U.S. pediatric hospitals investigated trends in group O blood usage.
  • Focus on identifying pediatric populations receiving group O blood despite non-group O blood type.

Purpose of the Study:

  • To analyze pediatric transfusion practices regarding group O red blood cells.
  • To clarify which pediatric patient groups receive group O blood transfusions when their blood type is non-O.
  • To inform strategies for optimizing blood supply and transfusion safety in children.

Main Methods:

  • Retrospective analysis of Electronic Health Records from eight pediatric institutions.
  • Inclusion of data on unit and patient blood type, age, sex, and diagnosis.
  • Utilized GPT-4 for diagnosis categorization and visualized data with alluvial plots, spaghetti plots, and stratified tables.

Main Results:

  • 142,227 transfusion events analyzed; 52,731 recipients had non-O blood types.
  • 67% of group O blood transfusions were given to A, B, or AB blood type recipients.
  • Cardiovascular disorders (22%) and sickle cell anemia (15%) were top diagnostic categories for group O blood recipients.

Conclusions:

  • Significant utilization of group O blood in non-O pediatric patients identified.
  • Opportunities exist to safely use non-O blood in specific pediatric populations.
  • Findings can help address challenges in maintaining an adequate group O red blood cell supply.
Abstract

Keywords:
O blood typeneonatepediatricssickle cell diseasetransfusion

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