Pathologies in a preterm infant exposed to methamphetamine in utero: Case report and literature review

Methamphetamine (M-AMP) use among women of childbearing age is a growing global concern Herein we present an unusual clinical presentation in a preterm infant born to a mother who used M-AMP during pregnancy. A 26-year-old woman, with no prenatal care, presented to the emergency department with aggressive behavior and visible skin wounds led to suspicion of substance abuse. Urine analysis confirmed high levels of amphetamines (2000 ng/mL). The infant was delivered by cesarean section at 30 + 5/7 weeks, with a birth weight of 1580 grams. The infant, admitted to the NICU due to respiratory distress and prematurity, initially required nasal CPAP and exhibited transient tachypnea. Enteral feeding was initiated at 24 hours of life but was halted due to feeding intolerance. Once the baby's symptoms subsided, enteral feeding was gradually reintroduced and slowly increased. The infant successfully transitioned to full enteral feeding by the 15th postnatal day. Cranial ultrasound revealed hyperechoic areas in the right parietal lobe, and subsequent MRI showed millimetric T1 hyperintense areas, indicative of parenchymal microischemia. Preterm infants exposed to methamphetamine in utero may not show typical withdrawal symptoms. Diagnostic challenges arise from prematurity, with significant impacts on brain development and potential neurocognitive deficits.