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Reducing early pregnancy loss with vitamin D3: an analysis of serum 1,25-(OH)D3 modulation and miscarriage risk

Qian Zhao1, Liangying Wang1, Hongqin Xiang1

  • 1Department of Obstetrics and Gynecology in Hangzhou First People's Hospital Tonglu Hospital in Zhejiang Province, Hangzhou, No. 899 Meilin Road, Chengnan Street, Tonglu, Hangzhou 311500, Zhejiang Province, China.

Journal of Clinical Biochemistry and Nutrition
|March 28, 2025
PubMed

Keywords:
early pregnancy lossimmune modulationmiscarriage preventionserum 1,25-(OH)D3vitamin D3 supplementation

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Role of Skin in Vitamin D Synthesis01:23

Role of Skin in Vitamin D Synthesis

The skin plays a crucial role in the synthesis of vitamin D, a vital nutrient for various physiological processes in the body. Vitamin D is unique because it can be synthesized in the skin through a series of chemical reactions triggered by exposure to ultraviolet B (UVB) radiation from sunlight.
The solar UV B rays (290-315 nm) are absorbed by the skin, and 7-dehydrocholesterol (provitamin D3) photolyzes it to previtamin D3, which undergoes a rapid transformation to vitamin D3(cholecalciferol).