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Updated: Jul 8, 2026

Gene Regulation and Targeted Therapy in Gastric Cancer Peritoneal Metastasis: Radiological Findings from Dual Energy CT and PET/CT
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Published on: January 22, 2018

Treatment Modalities and Survival Outcomes in Gastric Cancer: Insights From Najran, Saudi Arabia.

Ahmed M Badheeb1,2, Ibrahim A Alyami3, Ahlam Y Alyami4

  • 1Oncology, King Khalid Hospital, Najran, SAU.

Cureus
|March 28, 2025
PubMed
Summary

This study on gastric cancer (GC) in Najran found a 37.4% five-year survival rate. Female gender, advanced stage, and elevated CEA levels predict higher mortality, while neoadjuvant chemotherapy improves outcomes.

Keywords:
gastric cancermortalitynajransaudi arabiasurvival

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Area of Science:

  • Oncology
  • Gastroenterology
  • Epidemiology

Background:

  • Gastric cancer (GC) is a leading cause of cancer mortality globally.
  • Late diagnosis significantly reduces survival rates for GC patients.
  • This study focuses on GC treatment, survival, and mortality in Najran, Saudi Arabia.

Purpose of the Study:

  • To investigate treatment modalities for gastric cancer patients in Najran.
  • To analyze survival outcomes and identify mortality factors in this population.
  • To provide insights for improving patient management and outcomes.

Main Methods:

  • Retrospective analysis of 121 GC patients treated between 2014-2022.
  • Extraction and analysis of clinical, pathological, and treatment data.
  • Kaplan-Meier survival analysis and Cox regression for mortality risk factors.

Main Results:

  • Median age was 64 years; 71.1% were male.
  • Stage IV disease and elevated CEA levels were associated with increased mortality.
  • Neoadjuvant chemotherapy demonstrated a reduced mortality risk (HR: 0.55).

Conclusions:

  • The five-year survival rate for GC patients in Najran was 37.4%.
  • Female gender, advanced stage, and elevated CEA levels are significant mortality predictors.
  • Neoadjuvant chemotherapy is associated with improved survival, highlighting the need for personalized treatment.