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The Presence of Diffuse Idiopathic Skeletal Hyperostosis (DISH) among Patients with High Burden of Cardiovascular

Nadia Khalaily1, Leonid Roshkovan2, Amir Bieber3

  • 1Internal Medicine C Department, Ha'Emek MC, Afula, Israel.

International Journal of Rheumatology
|March 28, 2025
PubMed

Insights

Diffuse idiopathic skeletal hyperostosis (DISH) was not associated with major adverse cardiovascular events (MACE) in patients undergoing coronary angiography. However, a significant increase in myocardial infarction was observed in non-coronary heart disease patients with DISH.

Area of Science:

  • Cardiovascular Medicine
  • Rheumatology
  • Radiology

Background:

  • Diffuse idiopathic skeletal hyperostosis (DISH) is a systemic condition characterized by ossification of ligaments in at least four contiguous thoracic vertebrae.
  • Previous research suggests a link between DISH and increased cardiovascular morbidity.

Purpose of the Study:

  • To investigate the association between DISH, cardiovascular risk factors, and major adverse cardiovascular events (MACE).
  • To evaluate MACE, including myocardial infarction, ischemic stroke, and cardiovascular mortality, in patients undergoing coronary angiography.

Main Methods:

  • Retrospective analysis of 198 patients who underwent coronary angiography between May 2014 and April 2015.
  • Patients were categorized into four groups based on the presence of coronary heart disease (CHD) and DISH.
  • Follow-up was conducted for a median of 7 years to assess cardiovascular outcomes.

Main Results:

  • DISH was present in 44 patients with CHD and 35 without significant CHD at baseline.
  • The presence of DISH was not associated with overall mortality, cardiovascular death, ischemic stroke, or MACE.
  • A statistically significant increase in myocardial infarction events was noted in the non-CHD group with DISH.

Conclusions:

  • In patients with a high burden of cardiovascular risk factors undergoing coronary angiography, DISH is not associated with an increased incidence of MACE.
  • Further research may be warranted to explore the specific association between DISH and myocardial infarction in non-obstructive coronary heart disease populations.
Abstract

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