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Peripheral Nervous System Complications after COVID-19 Vaccination
Seyed Sepehr Khatami1, Samaneh Ghorbani Shirkouhi2, Poul Flemming Høilund-Carlsen3,4
1Department of Neurology, University of California Irvine, Irvine, CA 92617, USA.
Journal of Integrative Neuroscience
|March 28, 2025
Summary
Neurological complications, including peripheral nervous system issues, can occur after COVID-19 vaccination. Early diagnosis and management are key for conditions like inflammatory polyneuropathy and Parsonage-Turner syndrome.
Area of Science:
- Neurology
- Immunology
- Vaccinology
Background:
- Vaccination against SARS-CoV-2 (COVID-19) is vital, but neurological complications have been observed.
- These complications affect both the central and peripheral nervous systems (CNS and PNS).
Purpose of the Study:
- To review peripheral nervous system (PNS) complications following COVID-19 vaccination.
- To discuss their underlying mechanisms, diagnosis, and management strategies.
Main Methods:
- Literature review of reported PNS complications post-COVID-19 vaccination.
- Analysis of diagnostic criteria and treatment modalities for identified neuropathies.
Main Results:
- Reported PNS complications include inflammatory polyneuropathy, small fiber neuropathy, Parsonage-Turner syndrome (PTS), cranial mononeuropathies, and myasthenia gravis (MG).
- Early diagnosis based on clinical presentation and supportive care, potentially with immunoglobulin or plasmapheresis, is recommended for inflammatory polyneuropathy.
- Skin biopsy and needle electromyography are valuable diagnostic tools for small fiber neuropathy and PTS, respectively.
Conclusions:
- While COVID-19 vaccination can lead to neurological complications, the benefits of immunity outweigh the risks.
- Prompt recognition and appropriate management of PNS complications are essential for patient outcomes.
Keywords:
COVID-19SARS-CoV-2neurological complicationsperipheral nervous systemvaccinationvaccine safetyMore Related Videos
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