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Related Concept Videos

Parkinson's Disease: Overview01:15

Parkinson's Disease: Overview

Neurodegenerative disorders are progressive diseases that cause irreversible damage and loss to neurons in specific brain areas. Examples of these disorders include Parkinson's disease, Alzheimer's disease, Multiple Sclerosis (MS), and Amyotrophic Lateral Sclerosis (ALS). These disorders share characteristics such as proteinopathies, selective neuronal vulnerability, and a complex interplay between genetic and environmental factors. The primary therapeutic goal for these conditions is to...
Parkinson's Disease: Treatment01:24

Parkinson's Disease: Treatment

Neurodegenerative disorders, such as Parkinson's Disease (PD), involve the gradual and irreversible destruction of neurons in particular brain areas. These disorders exhibit standard features like proteinopathies, selective vulnerability of some neurons, and an interaction of intrinsic properties, genetics, and environmental influences in neural injury.
Parkinson's Disease is primarily a result of the loss of dopaminergic neurons in the substantia nigra pars compacta. The cornerstone of its...
Seizures: Classification01:13

Seizures: Classification

Epilepsy is primarily characterized by unpredictable seizures, either provoked by an identifiable factor, such as injury or illness, or unprovoked, occurring spontaneously without apparent cause.
Seizures are typically classified into two main categories: focal and generalized seizures.
Focal Seizures
Focal seizures originate from specific regions of the brain. These seizures are further sub-classified into two types:
Parkinson Disease l: Introduction01:24

Parkinson Disease l: Introduction

Parkinson’s disease is a chronic, progressive neurodegenerative disorder that primarily affects movement. It is characterized by motor symptoms such as resting tremors, muscle rigidity, bradykinesia (slowness of movement), and postural instability. Patients may notice hand tremors at rest, stiffness during movement, or a shuffling gait. In addition to motor features, non-motor symptoms include sleep disturbances, mood and behavioral changes, constipation, and cognitive impairment, all of which...
Parkinson Disease ll: Pathophysiology01:24

Parkinson Disease ll: Pathophysiology

Parkinson disease (PD) is a progressive neurodegenerative disorder primarily affecting movement, with additional non-motor features. Its pathophysiology involves complex interactions among genetic susceptibility, environmental exposures, and cellular dysfunction, including dopaminergic neuron loss, protein aggregation, and mitochondrial impairment.Selective NeurodegenerationA key feature is the degeneration of dopaminergic neurons in the substantia nigra pars compacta, leading to reduced...
Seizures ll: Types01:19

Seizures ll: Types

Seizures are sudden bursts of abnormal electrical discharge in the brain that interfere with normal function. They are commonly divided into three groups: focal seizures, generalized seizures, and other types that do not fit neatly into either category.Focal SeizuresFocal seizures begin in a single brain region. When awareness is preserved, they are called focal aware seizures and may cause sensations such as tingling, unusual smells, or flashing lights. When awareness is impaired, they are...

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Generalized Tremors in Dogs: 198 Cases (2003-2023).

Theofanis Liatis1, Sofie F M Bhatti2, Steven De Decker1

  • 1Department of Clinical Science and Services, Royal Veterinary College, Hatfield, UK.

Journal of Veterinary Internal Medicine
|March 28, 2025
PubMed
Summary
This summary is machine-generated.

Generalized tremors in dogs are most commonly caused by intoxication or idiopathic generalized tremor syndrome (IGTS). Clinical signs and history can help differentiate these conditions, guiding diagnosis and treatment for canine tremor disorders.

Keywords:
corticosteroid‐responsive tremor syndromeidiopathic cerebellitisidiopathic generalized tremor syndromeintoxicationmycotoxicosiswhite shaker disease

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Area of Science:

  • Veterinary Neurology
  • Canine Medicine
  • Toxicology

Background:

  • Generalized tremors in dogs are not well-studied in large populations.
  • Understanding the underlying causes is crucial for effective treatment.

Purpose of the Study:

  • To describe the clinical signs, tremor characteristics, and associated diseases in dogs with generalized tremors.
  • To identify clinical features that can help diagnose the underlying cause of tremors.

Main Methods:

  • Retrospective study of 198 dogs diagnosed with generalized tremors between 2003 and 2023.
  • Analysis of clinical data, including semiology, signalment, and diagnostic outcomes.

Main Results:

  • Intoxication (46%) and idiopathic generalized tremor syndrome (IGTS, 24.7%) were the most frequent causes.
  • Distinct clinical presentations differentiated IGTS (younger, female, lateralizing signs) from intoxication (male, variable age, symmetric signs).
  • Specific clinical signs like behavioral changes, hypersalivation, and mentation changes were more common in intoxication, while hyporexia and vestibulocerebellar signs suggested IGTS.

Conclusions:

  • Intoxication and IGTS are the primary differential diagnoses for generalized tremors in dogs.
  • Clinical and historical data are valuable for differentiating causes and informing diagnostic and treatment strategies.