The Role of Advanced Glycation End Products in the Etiology of Premature Ventricular Contractions

Alkame Akgümüş ¹, Ali Duygu ²

⁰Department of Cardiology, Bandırma Onyedi Eylül University, Faculty of Medicine, Balıkesir, Türkiye.

Türk Kardiyoloji Derneği Arşivi : Türk Kardiyoloji Derneğinin Yayın Organıdır +

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March 28, 2025

View abstract on PubMed

Summary

Advanced glycation end products (AGEs) are higher in patients with frequent premature ventricular contractions (PVC). Higher AGE levels are linked to an increased PVC burden, suggesting a potential role in PVC development.

Area Of Science

Cardiology
Biochemistry
Medical Diagnostics

Background

Premature ventricular contractions (PVC) mechanisms, including automaticity, triggered activity, and reentry, are not fully understood.
Advanced glycation end products (AGEs) are implicated in contributing to these PVC mechanisms.

Purpose Of The Study

To compare AGE levels in patients with and without a high PVC burden (≥ 5% in 24-hour Holter monitoring).

Main Methods

Two groups were formed: a PVC case group (≥ 5% PVC burden) and a control group (< 5% PVC burden), each with 65 patients.
Skin AGE levels were quantified using a spectrophotometric method.

Main Results

Patients with a high PVC burden exhibited significantly higher AGE levels (2.6 AU) compared to controls (2.0 AU) (P < 0.001).
Receiver operating characteristics analysis showed an area under the curve of 0.760 for detecting a PVC burden > 5%.
An AGE level of 2.4 AU demonstrated 61.5% sensitivity and 80% specificity for identifying a high PVC burden.

Conclusions

Elevated AGE levels are independently and positively associated with a high PVC burden.
AGEs may play a significant role in the pathophysiology of frequent premature ventricular contractions.

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