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Genome-wide Screen for miRNA Targets Using the MISSION Target ID Library
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The effects of flavonoid baicalein on miRNA expressions in cancer: a systematic review

Mohanna Khandan1, Mohammad Amin Khazeei Tabari1, Seyed Mostafa Rahimi2

  • 1Mazandaran University of Medical Sciences, Sari, Iran.

Naunyn-Schmiedeberg'S Archives of Pharmacology
|March 28, 2025
PubMed

Insights

Baicalein, a compound from Scutellaria baicalensis, alters microRNA (miRNA) expression in multiple cancers. This natural compound shows promise for novel cancer therapies by influencing key tumor growth and metastasis pathways.

Area of Science:

  • Phytochemistry and Molecular Oncology
  • Cancer Biology and Therapeutics

Background:

  • MicroRNAs (miRNAs) are critical regulators of gene expression involved in cancer pathogenesis.
  • Baicalein, derived from Scutellaria baicalensis, has demonstrated anti-cancer properties.
  • Understanding baicalein's impact on miRNA expression is crucial for developing targeted cancer therapies.

Purpose of the Study:

  • To systematically review the effects of baicalein on miRNA expression across various cancer types.
  • To consolidate evidence on baicalein's influence on cancer-related signaling pathways and cellular processes.

Main Methods:

  • A comprehensive systematic review following PRISMA guidelines.
  • Searches of PubMed, Scopus, and Web of Science databases.
  • Inclusion of studies on baicalein treatment in cancer cell lines and animal models, with risk of bias assessment.

Main Results:

  • Fifteen studies revealed baicalein modulates miRNA expression in hepatocellular carcinoma, breast, cervical, ovarian, and gastric cancers.
  • Baicalein regulates key cancer genes (e.g., HDAC10, MDM2) and signaling molecules (e.g., AKT, FOXO3α).
  • Evidence supports baicalein's inhibition of tumor growth, enhancement of apoptosis, and regulation of cell proliferation in vitro and in vivo.

Conclusions:

  • Baicalein shows potential as a multi-cancer therapeutic agent by influencing miRNA expression.
  • Targeted modulation of miRNA expression by baicalein offers promising avenues for novel cancer treatment strategies.
  • Future research emphasizing methodological rigor is essential to validate baicalein's therapeutic potential.
Keywords:
BaicaleinCancerFlavonoidMiRNA

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