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Updated: Jul 15, 2026

A Simple Method for Automated Solid Phase Extraction of Water Samples for Immunological Analysis of Small Pollutants
Published on: January 1, 2016
MIL-125@ZIF-8 based solid phase microextraction coating for sensitive determination of organophosphate esters in
Xingru Hu1, Jiahui Hou1, Long Pang2
1School of Material and Chemical Engineering, Zhengzhou University of Light Industry, Zhengzhou, 450002, China.
Abstract:
A novel MOF-on-MOF heterostructure (MIL-125@ZIF-8) was synthesized and utilized as a coating material for solid-phase microextraction (SPME), which was subsequently coupled with gas chromatography (GC) for the sensitive determination of organophosphate esters (OPEs) in water samples. Compared to commercial fiber, the MIL-125@ZIF-8 coated fiber (MIL-125@ZIF-8-F) demonstrated superior extraction performance for medium-polar or non-polar compounds due to multiple interactions such as hydrophobic interaction, π-π stacking, and hydrogen bonding. The synergistic effect of MIL-125 and ZIF-8 endowed the MIL-125@ZIF-8-F with high efficiency and excellent stability under extreme conditions. Specifically, the developed MIL-125@ZIF-8-F could withstand 80 conditioning cycles without significant loss of extraction capacity. Moreover, the established method exhibited a wide linear range (10-1000 μg L-1), low detection limits (0.03-0.20 μg L-1), and excellent reproducibility under optimized condition. Finally, this proposed method provided a promising approach for the efficient enrichment of trace OPEs in actual environmental water samples.
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