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Updated: Jul 16, 2026

Surgical Retrieval, Isolation and In vitro Expansion of Human Anterior Cruciate Ligament-derived Cells for Tissue Engineering Applications
Published on: April 30, 2014
The intricate link between anterior cruciate ligament rupture and lower limb muscle fatigue: a case study
Zeynab Saghaeinooshabadi1, Mohammad Reza Zakerzadeh1, Mohmmad Ali Nazari2
1School of Mechanical Engineering, College of Engineering, University of Tehran, Tehran, Iran.
Purpose:
This study aims to explore the impact of Anterior Cruciate Ligament (ACL) injuries on the fatigue behavior of selected lower limb muscles during high-intensity physical activity.
Methods:
The study involves assessing the surface electromyographic activity of key muscle groups, including the hamstrings, quadriceps, and triceps surae (Biceps Femoris (BF), Semitendinosus (ST), Rectus Femoris (RF), Vastus Lateralis (VL), Vastus Medialis (VM), GastroCnemius Lateralis (GCL), GastroCnemius Medialis (GCM), and Soleus (S)), in an individual with a left leg ACL rupture. Muscle activity has been monitored during a fatigue protocol, and metrics such as Root Mean Square (RMS), Median Frequency (MDF), and Integrated Electromyography (IEMG) have been calculated to evaluate muscle function.
Results:
Significant reductions in electromyographic parameters are observed in the BF, ST, VM, and VL of the injured leg and in the GCL of the contralateral leg during the fatigue protocol.
Conclusions:
These findings enhance the understanding of how ACL injuries influence the neuromuscular function of both the affected and unaffected legs during prolonged activity. This knowledge provides valuable insights into knee joint loading mechanics and may inform strategies for addressing muscle fatigue and optimizing rehabilitation protocols.
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