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Lower circulating IGF-1 levels in fibromyalgia: meta-analysis highlighting potential pathogenic role
1Department of Rheumatology, Korea University College of Medicine, Seoul, Korea. lyhcgh@korea.ac.kr.
Clinical and Experimental Rheumatology
|March 28, 2025
Summary
This meta-analysis found that insulin-like growth factor 1 (IGF-1) levels are significantly lower in individuals with fibromyalgia. These findings suggest IGF-1 may be involved in the development of fibromyalgia.
Area of Science:
- Endocrinology and Metabolism
- Rheumatology and Autoimmune Diseases
Background:
- Fibromyalgia is a chronic condition characterized by widespread pain and fatigue.
- Circulating levels of insulin-like growth factor 1 (IGF-1) have been investigated for their potential role in fibromyalgia pathogenesis.
Approach:
- A meta-analysis was conducted to compare serum/plasma IGF-1 levels between fibromyalgia patients and healthy controls.
- Subgroup analyses were performed based on region, sample size, data type, publication year, and matched variables (age, sex, BMI).
Key Points:
- Initial analysis did not show significantly decreased IGF-1 levels in fibromyalgia patients (SMD=-0.347, p=0.089).
- Sensitivity analysis revealed instability, with one study significantly affecting pooled results (SMD=-0.458, p=0.014).
- After adjusting for publication bias, IGF-1 levels were significantly lower (SMD=-0.513, p=0.001).
- Stratification by data type (original data) and recent publication year (>2012) also showed significantly lower IGF-1 levels in fibromyalgia patients.
Conclusions:
- This meta-analysis indicates significantly lower IGF-1 levels in patients with fibromyalgia.
- IGF-1 may play a crucial role in the underlying mechanisms and development of fibromyalgia.
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