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Subjective Physical Performance and Its Determinants in Patients With Haemophilia
Alexander Schmidt1, Fabian Tomschi1, Pia Möllers1
1Department of Sports Medicine, University of Wuppertal, Wuppertal, Germany.
Summary
Patients with haemophilia (PwH) report significantly lower subjective physical performance (SPP) than healthy individuals. Arthropathy, particularly joint status and pain, are key factors negatively impacting SPP in PwH.
Area of Science:
- Orthopedics and Sports Medicine
- Hematology
- Rehabilitation Medicine
Background:
- Physical functioning is often impaired in patients with haemophilia (PwH).
- Factors influencing subjective physical performance (SPP) in PwH are not fully understood.
- This study investigates SPP in PwH compared to healthy controls (CON).
Purpose of the Study:
- To compare SPP between PwH and CON.
- To differentiate SPP based on disease-specific, person-related, and arthropathy-related parameters.
- To identify key determinants influencing SPP in PwH.
Main Methods:
- Assessed SPP using the HEP-Test-Q in 301 PwH and 263 CON.
- Evaluated disease-specific (type, severity, treatment, HIV, hepatitis), person-related (age, BMI), and arthropathy-related parameters (pain intensity, HJHS).
- Utilized multiple linear regression to identify associations with SPP.
Main Results:
- PwH exhibited significantly lower SPP across all dimensions compared to CON.
- SPP differences were noted in PwH based on severity, treatment, HIV, and hepatitis status.
- Joint Health and எலும்பு முறிவு Score (HJHS) and average pain intensity (NRS-4w) significantly predicted total SPP.
Conclusions:
- PwH perceive their physical performance as substantially worse than CON.
- Arthropathy-related factors, including joint status and persistent pain, are primary contributors to decreased SPP.
- Tailored sports-therapeutic programs are recommended to mitigate SPP decline in PwH.
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