Related Experiment Video
Updated: May 6, 2026

09:37
Microfabrication of Chip-sized Scaffolds for Three-dimensional Cell cultivation
Published on: May 13, 2008
11.4K
Scalable fabrication of Chip-integrated 3D-nanostructured electronic devices via DNA-programmable assembly
Aaron Michelson1, Lior Shani2, Jason S Kahn1
1Center for Functional Nanomaterials, Brookhaven National Laboratory, Upton, NY 11973, USA.
Science Advances
|March 28, 2025
Summary
Researchers developed a new nanofabrication method for precise 3D DNA superlattice growth on surfaces. This technique enables the creation of novel self-assembled nanostructured electronic devices with controlled placement and orientation.
Area of Science:
- Nanotechnology
- Materials Science
- Biotechnology
Background:
- DNA self-assembly offers precise control over nanomaterial structures.
- Integrating DNA superlattices with conventional nanofabrication for 3D devices remains challenging.
Purpose of the Study:
- To develop a scalable nanofabrication technique for selective growth of 3D DNA superlattices.
- To enable the fabrication of self-assembled 3D-nanostructured electronic devices.
Main Methods:
- Combined bottom-up and top-down nanofabrication approaches.
- Utilized gold microarrays to anchor DNA strands and guide DNA origami framework growth.
- Templated DNA frameworks into nanoscale silica and tin oxide (SnOx).
Main Results:
- Achieved selective growth of 3D DNA superlattices on specific surface locations.
- Demonstrated controlled lateral placement and orientation of DNA superlattices.
- Fabricated SnOx superlattices integrated into devices exhibiting photocurrent response.
Conclusions:
- The presented technique successfully integrates DNA self-assembly with nanofabrication for 3D device construction.
- This method allows for the creation of functional nanostructured electronic devices with precise control.
- The approach holds promise for advancing the field of DNA-assembled functional devices.

