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Updated: Jul 13, 2026

Techniques to Induce and Quantify Cellular Senescence
Published on: May 1, 2017
Lactylation: A Novel Epigenetic Regulator of Cellular Senescence
Caiyu Sun1,2,3,4,5, Jiaxuan Li1,3,4,5, Lei Dong1,3,4,5
1Department of Otorhinolaryngology, mHead and Neck Surgery, Yantai Yuhuangding Hospital, Qingdao University, Yantai, Shandong, China.
Abstract:
Cellular senescence is the basic unit of organismal aging, a complicated biological process involving several cell types and tissues. It is also an important mechanism by which the body responds to damage and potential carcinogenesis. However, excessive or abnormal cellular senescence can lead to tissue functional degradation and the occurrence of diseases. In recent years, the role of epigenetic modifications in cellular senescence has received extensive attention. Lactylation, a novel post-translational modification derived from lactate, has recently gained significant attention as a key factor in cellular metabolism and epigenetic regulation, gradually demonstrating its importance in the regulation of cellular senescence. This review emphasizes the bidirectional causal relationship between lactylation and cellular senescence, highlighting its potential as a therapeutic target for aging-related diseases.
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