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Updated: Jun 19, 2026

Distinctive Capillary Action by Micro-channels in Bone-like Templates can Enhance Recruitment of Cells for Restoration of Large Bony Defect
Published on: September 11, 2015
Enhanced bone regeneration via surface functionalization of biphasic calcium phosphate scaffolds with
Luhui Zhang1, Jiajia Fan2, Lin Ding2
1Schcool of Art and Media, Guangzhou Vocational University of Science and Technology, Guangzhou, Guangdong 510641, PR China; School of Materials Science and Engineering, South China University of Technology, Guangzhou 510641, PR China.
Abstract:
Rapid induction of angiogenesis is crucial for the treatment of large bone defects and accelerating the material-mediated bone defect repair process. In this study, we employed a negative pressure infiltration method to coat the surface of porous BCP scaffolds with dopamine-modified hyaluronic acid (HA-DA) hydrogel and magnesium-doped calcium silicate (Mg-CS). In vitro results demonstrated that HA-DA hydrogel coating with an appropriate degree of dopamine grafting significantly improved the in vitro angiogenic activity of BCP scaffolds without affecting their osteogenic activity. The Mg-CS coating, heat-treated to ensure good combination with the BCP matrix, could sustainably release angiogenic silicon ions and osteogenic magnesium ions. Results from rat cranial defect repair showed that the implanted BCP@HA-DA-2 and BCP@10 Mg-CS scaffolds further accelerated the occurrence and development of neovascularization at the defect site, facilitating new bone formation. Among them, BCP@10 Mg-CS scaffold exhibited the best bone defect repair effect and has the potential for clinical application.
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