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Updated: Aug 8, 2026

Engineering a Bilayered Hydrogel to Control ASC Differentiation
Published on: May 25, 2012
Multifunctional alginate-sinapic acid/arginine-strontium hydrogel for promoting diabetic wound healing
Jie Liu1, Ying Fu1, Wenlin Jia1
1College of Pharmaceutical Science & Key Laboratory of Medicinal Chemistry and Molecular Diagnosis of the Ministry of Education, China State Key Laboratory of New Pharmaceutical Preparations and Excipients, Key Laboratory of Pharmaceutical Quality Control of Hebei Province, Hebei University, Baoding 071002, China.
Abstract:
Sodium alginate (Alg), sinapic acid (SA), arginine (Arg), strontium carbonate (SrCO₃), and D-gluconic acid δ-lactone (GDL) were employed to construct an ionically crosslinked sodium alginate-sinapic acid/arginine‑strontium (ASASG) hydrogel. This study aims to evaluate its potential for enhancing diabetic wound repair through combined ionic crosslinking and bioactive component synergy. The hydrogel demonstrates exceptional swelling properties conducive to the absorption of wound exudate. Furthermore, it exhibits remarkable antibacterial and antioxidant activities. The ASASG hydrogel shows good biocompatibility, facilitates hemostasis and promotes the migration of NIH 3 T3 fibroblasts. Animal studies have revealed that ASASG hydrogel significantly enhances wound healing, accelerates re-epithelialization, and fosters collagen deposition in diabetic rats. Furthermore, ASASG hydrogels mitigated inflammatory cell infiltration by down-regulating IL-6 expression and concurrently up-regulating TGF-β expression. Notably, ASASG hydrogels also stimulate angiogenesis by enhancing the expressions of VEGF and bFGF. Therefore, the use of ASASG hydrogel in the treatment of diabetic wounds is a possible therapeutic approach.
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