Prurigo Nodularis: A historic perspective

Prurigo nodularis (PN) is a chronic inflammatory skin condition characterized by firm, itchy nodules and relentless itch. PN was first described in the 19th century. After observations of various dermatologists, the clinical presentation was officially given a name in 1909 by James Nevins Hyde. Throughout the 1900s, PN gained pockets of attention concerning its histopathologic features, epidemiology, and pathophysiology, although it existed as a largely ambiguous disease for many years. Only at the turn of the 21st century was the recognition of PN reignited, prompting extensive research and leading to striking advancements in our understanding of the mechanisms that had contributed to PN during the last decade. Despite a long and inconsistent course, there are now definitive immune and neural pathways that can be selectively targeted with novel therapies, suggesting a promising future for managing this debilitating condition.