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The Predictive Value of the CHA2DS2-VASc Score in the Development of Contrast-Induced Nephropathy after Endovascular

Ali Evsen1, Adem Aktan2, Raif Kılıç2

  • 1Dağkapı State Hospital, Department of Cardiology, Diyarbakır, Turkey.

Annals of Vascular Surgery
|March 28, 2025
PubMed

Insights

The CHA2DS2-VASc score predicts contrast-induced nephropathy (CIN) in peripheral artery disease (PAD) patients undergoing endovascular procedures. A higher score indicates increased risk for developing CIN, aiding in risk stratification.

Area of Science:

  • Cardiology
  • Nephrology
  • Vascular Surgery

Background:

  • Contrast-induced nephropathy (CIN) is a significant complication following endovascular interventions for peripheral artery disease (PAD).
  • CIN is associated with adverse outcomes including renal dysfunction, prolonged hospitalization, and increased mortality.
  • The CHA2DS2-VASc score, typically used for cardioembolic risk, shares risk factors with CIN.

Purpose of the Study:

  • To evaluate the predictive capability of the CHA2DS2-VASc score for CIN development in PAD patients.
  • To determine if the CHA2DS2-VASc score can serve as a risk stratification tool for CIN.

Main Methods:

  • A retrospective analysis of 754 PAD patients undergoing endovascular procedures was conducted.
  • Patients were stratified by CHA2DS2-VASc score (low <3, high ≥3) and monitored for CIN development.
  • Univariate and multivariate regression analyses identified independent predictors of CIN.

Main Results:

  • 178 (23.6%) patients developed CIN, with 84.8% in the high CHA2DS2-VASc score group (P < 0.001).
  • The CHA2DS2-VASc score was significantly higher in CIN-positive patients (P < 0.001).
  • Independent predictors of CIN included CHA2DS2-VASc score (OR: 1.574), baseline creatinine, and hemoglobin.

Conclusions:

  • The CHA2DS2-VASc score is an independent predictor of CIN in PAD patients undergoing endovascular intervention.
  • This score can aid clinicians in identifying high-risk patients for CIN.
Abstract

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