Association Between Kita-kyushu Lung Cancer Antigen-1 Expression in Gastric Cancer and Helicobacter pylori-infection Status
- Nobue Futawatari 1,2, Takashi Fukuyama 3, Yusuke Akimoto 2, Junji Maehara 2, Daisuke Hihara 4, Yosuke Okamoto 4, Yuki Yokouchi 5, Kei Takahashi 5, Manabu Watanabe 2, Yoshihisa Saida 2
- Nobue Futawatari 1,2, Takashi Fukuyama 3, Yusuke Akimoto 2
- 1Department of Surgery, NHO Sagamihara National Hospital, Sagamihara, Japan.
- 2Department of Surgery, Toho University Ohashi Medical Center, Tokyo, Japan.
- 3Division of Biomedical Research, Kitasato University Medical Center, Kitamoto, Japan; fukuyam@insti.kitasato-u.ac.jp.
- 4Department of Gastroenterology, Toho University Ohashi Medical Center, Tokyo, Japan.
- 5Department of Pathology, Toho University Ohashi Medical Center, Tokyo, Japan.
- 0Department of Surgery, NHO Sagamihara National Hospital, Sagamihara, Japan.
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View abstract on PubMed
Summary
This summary is machine-generated.Kita-kyushu lung cancer antigen-1 (KK-LC-1) is highly expressed in gastric cancer (GC) patients with a history of Helicobacter pylori (Hp) infection and successful Hp eradication. This suggests KK-LC-1 may play a role in GC development independent of Hp status.
Area Of Science
- Oncology
- Gastroenterology
- Immunology
Background
- Kita-kyushu lung cancer antigen-1 (KK-LC-1), a cancer/testis antigen (CTA), is frequently expressed in gastric cancer (GC) tissues.
- KK-LC-1 expression is linked to Helicobacter pylori (Hp) infection, but the relationship between Hp eradication and GC incidence remains unclear.
Purpose Of The Study
- To investigate the association between KK-LC-1 expression and Hp eradication in patients with GC.
- To explore the potential independent role of KK-LC-1 in GC development.
Main Methods
- Analysis of KK-LC-1 expression in tumor and non-tumor tissues from 124 GC patients.
- Investigation of associations between KK-LC-1 expression and 14 clinicopathological factors, including Hp infection and eradication status.
- Statistical analysis using Fisher's exact test and multivariable regression.
Main Results
- KK-LC-1 was expressed in 74.2% of cancerous tissues from GC patients.
- KK-LC-1 expression correlated with older age, deeper invasion, differentiated type, absence of lymph node metastasis, Hp eradication, prior Hp infection, and multiple cancers.
- High KK-LC-1 expression was observed in GC cases with previous Hp infection and successful eradication.
Conclusions
- KK-LC-1 expression is prevalent in GC, particularly in patients with a history of Hp infection and successful eradication.
- The expression pattern of KK-LC-1 suggests a potential role in GC pathogenesis independent of Hp infection status.
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