Platelet-derived Growth Factor Receptor-α as a Biomarker for Tongue Spindle Cell Carcinoma
- Takehito Ouchi 1,2, Satoru Morikawa 3, Taneaki Nakagawa 3, Seiji Asoda 4
- Takehito Ouchi 1,2, Satoru Morikawa 3, Taneaki Nakagawa 3
- 1Department of Dentistry and Oral Surgery, Keio University School of Medicine, Tokyo, Japan; takehitoo@tdc.ac.jp.
- 2Department of Physiology, Tokyo Dental College, Tokyo, Japan.
- 3Department of Dentistry and Oral Surgery, Keio University School of Medicine, Tokyo, Japan.
- 4Department of Dentistry and Oral Surgery, Keio University School of Medicine, Tokyo, Japan; asoda@keio.jp.
- 0Department of Dentistry and Oral Surgery, Keio University School of Medicine, Tokyo, Japan; takehitoo@tdc.ac.jp.
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View abstract on PubMed
Summary
This summary is machine-generated.Mesenchymal stem/stromal cells (MSCs), particularly those expressing PDGFRα, expand in spindle cell carcinoma (SpCC) and may drive epithelial-mesenchymal transition. Targeting PDGFRα could offer new therapeutic strategies for this aggressive cancer.
Area Of Science
- Oncology
- Cancer Biology
- Stem Cell Research
Background
- Spindle cell carcinoma (SpCC) is a rare, aggressive squamous cell carcinoma subtype with unclear characteristics and a poor prognosis.
- Effective treatment strategies for SpCC require specialized approaches distinct from conventional squamous cell carcinoma treatments.
Purpose Of The Study
- To investigate the distribution and role of mesenchymal stem/stromal cells (MSCs), specifically PDGFRα-expressing MSCs, within SpCC.
- To explore the potential involvement of MSCs in epithelial-mesenchymal transition (EMT) in SpCC.
Main Methods
- Immunohistological analysis of tissue sections to detect immunopositive signals for MSC markers, including PDGFRα.
- Examining the spatial relationship between MSCs and cancer epithelial cells (EpCAM-positive).
Main Results
- An expansion of PDGFRα-positive MSCs and other MSC markers was observed within SpCC tissue.
- MSCs were found adjacent to EpCAM-positive cancer epithelial cells.
- Some EpCAM-positive cells were surrounded by cancer-associated fibroblasts and showed MSC marker positivity.
Conclusions
- MSC expansion, particularly PDGFRα-positive MSCs, is associated with EpCAM-positive areas in SpCC.
- MSCs may function as cancer niche elements promoting EMT in SpCC.
- Targeting PDGFRα presents a potential therapeutic avenue for SpCC, aiding in understanding tumor biology and developing novel treatments.
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