Related Experiment Video
Updated: Jun 24, 2026

Assessment of Maternal Vascular Remodeling During Pregnancy in the Mouse Uterus
Published on: December 5, 2015
Valve-in-Valve Transcatheter Aortic Valve Replacement for Bioprosthetic Aortic Valve Disease in Pregnancy
Elissa Driggin1, Jason Bloom1, Susheel Kodali1
1Division of Cardiology, Department of Medicine, Columbia University Irving Medical Center, New York, New York, USA.
Background:
Management of valvular disease in pregnancy is complex. Hemodynamic changes associated with pregnancy may exacerbate underlying disease.
Case Summary:
A 32-year-old woman with a history of remote bioprosthetic aortic valve replacement (AVR) presented to care in early pregnancy with progressive dyspnea on exertion. Examination and an echocardiogram revealed moderate to severe bioprosthetic aortic stenosis and severe aortic insufficiency. The patient underwent valve-in-valve transcatheter AVR in the second trimester as a bridge to an uncomplicated term vaginal delivery. She was discharged on postpartum day 2.
Discussion:
Structural valve degeneration may be accelerated in pregnancy. Although regurgitant lesions are generally well tolerated, mixed aortic valve lesions may represent a higher-risk phenotype exacerbated by hemodynamic changes of pregnancy and may require intervention.
Take Home Message:
A multidisciplinary cardio-obstetrics team is essential to manage patients with severe, symptomatic valvular heart disease effectively during pregnancy.
More Related Videos
Related Concept Videos
Development of Blood Vessels
The initial formation of this system is facilitated by the small amount of yolk present in the ovum and yolk sac. Blood vessels originate from...
Fetal Circulation
Two umbilical arteries transport blood from the fetus to the placenta. At the placenta, the blood absorbs oxygen and nutrients while simultaneously eliminating waste products. This oxygen-enriched and nutrient-rich blood then returns to the fetus through one...
Mitral Valve Prolapse I: Introduction
Mitral Valve Prolapse III: Nursing Management

