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Updated: Jun 25, 2026
05:31
Noninvasive Sampling of Mucosal Lining Fluid for the Quantification of In Vivo Upper Airway Immune-mediator Levels
Published on: August 7, 2017
Correlation between peripheral blood basophils and chronic sinusitis with nasal polyps in different age groups
Lingling Xu1,2
1Department of Otorhinolaryngology Head and Neck Surgery, Fuzhou University Affiliated Provincial Hospital, Fuzhou, China. 15750843249@163.com.
Summary
Blood basophil counts may indicate inflammation severity in chronic rhinosinusitis with nasal polyps (CRSwNP). Further research into pediatric CRSwNP long-term outcomes is recommended.
Area of Science:
- Immunology
- Otolaryngology
- Respiratory Medicine
Background:
- Chronic rhinosinusitis with nasal polyps (CRSwNP) affects up to 4% of the population and significantly impacts quality of life.
- Despite advances, CRSwNP remains challenging to cure, necessitating further investigation into its underlying inflammatory mechanisms.
Purpose of the Study:
- To assess the role of blood basophils as inflammatory markers in CRSwNP.
- To investigate differences in inflammatory cell counts across pediatric, adult, and geriatric CRSwNP patient groups.
Main Methods:
- Retrospective analysis of 316 CRSwNP patients undergoing endoscopic sinus surgery (ESS).
- Patients were categorized into three age groups: pediatric (≤18 years), adult (19-60 years), and geriatric (≥61 years).
- Blood cell counts (basophils, lymphocytes, monocytes, eosinophils, WBC) and Lund-Mackay (LM) scores were analyzed.
Main Results:
- Blood basophil, lymphocyte, and monocyte counts, along with LM scores, showed significant differences between age groups, particularly between pediatric and adult/geriatric cohorts.
- No significant differences were observed in white blood cell (WBC) or eosinophil counts across the groups.
- Spearman correlation analysis revealed a positive correlation between blood basophil counts and eosinophils, leukocytes, lymphocytes, monocytes, and LM scores.
Conclusions:
- Blood basophil counts may serve as a valuable indicator of inflammation severity in CRSwNP patients.
- The findings suggest a heterogeneous role of blood basophils across different age groups in CRSwNP.
- Long-term follow-up of pediatric CRSwNP patients is crucial for understanding disease progression and management.
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