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Author Correction: Microglial mechanisms drive amyloid-β clearance in immunized patients with Alzheimer's disease

Lynn van Olst1,2, Brooke Simonton1,2, Alex J Edwards1,2

  • 1Abrams Research Center on Neurogenomics, Northwestern University Feinberg School of Medicine, Chicago, IL, USA.

Nature Medicine
|March 29, 2025
PubMed
Abstract

No abstract available in PubMed .

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Alzheimer Disease ll: Pathophysiology01:23

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Alzheimer disease involves structural changes in the brain that begin long before symptoms appear. The most distinctive features are extracellular neuritic plaques and intracellular neurofibrillary tangles.Neuritic plaques form in the cerebral cortex and around blood vessels. These plaques contain a dense core of beta-amyloid (Aβ)—a toxic protein fragment that clumps outside neurons. The core is surrounded by damaged neuronal extensions, as well as reactive astrocytes and microglia. Abnormal...

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