Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Equilibrium and Balance01:15

Equilibrium and Balance

The inner ear assumes dual functionalities of auditory perception and equilibrium maintenance. The vestibule is the organ responsible for balance. This organ contains mechanoreceptors, specifically hair cells, endowed with stereocilia, which aid in deciphering information regarding the position and motion of our heads. Two intrinsic components, the utricle and saccule, help perceive head position, while the semicircular canals track head movement. Neurological messages initiated in the...
Increased Intracranial Pressure l: Introduction01:14

Increased Intracranial Pressure l: Introduction

Intracranial hypertension is a sustained elevation of intracranial pressure (ICP) above 22 mm Hg. In supine adults, normal ICP is ~7–15 mm Hg.The rigid, nonexpandable cranium contains three components—brain tissue, blood, and cerebrospinal fluid (CSF)—that total ~1,700 mL in a typical adult: 1,400 mL brain (~80%), 150 mL blood (~10%), and 150 mL CSF (~10%). According to the Monro–Kellie doctrine, total intracranial volume is effectively fixed. When one component expands, CSF and venous blood...
Increased Intracranial Pressure ll: Pathophysiology01:29

Increased Intracranial Pressure ll: Pathophysiology

Increased intracranial pressure (ICP) refers to a potentially life-threatening rise in pressure inside the skull. This usually happens when there is a major change in the volume of brain tissue, blood, or cerebrospinal fluid (CSF) — the three components inside the skull. According to the Monro-Kellie doctrine, if the volume of one component increases, the volumes of the other components must decrease to maintain normal pressure. If this does not happen, ICP rises.The process often begins with...
Cerebral Edema l: Introduction01:19

Cerebral Edema l: Introduction

Cerebral edema is a pathological increase in brain water content that disrupts intracranial pressure regulation and impairs neurological function. Because the cranial vault is rigid, even modest increases in tissue volume can compromise cerebral perfusion, distort neural structures, and initiate secondary injury. Cerebral edema develops through four principal mechanisms: vasogenic, cytotoxic, interstitial, and ionic.Vasogenic EdemaVasogenic edema arises from disruption of the blood–brain...
Cerebral Edema ll: Pathophysiology01:22

Cerebral Edema ll: Pathophysiology

Vasogenic edema is a major form of cerebral edema characterized by abnormal accumulation of fluid in the brain’s extracellular space due to disruption of the blood–brain barrier (BBB). The BBB is a specialized structure composed of endothelial cells connected by tight junctions, supported by astrocytic endfeet and a basement membrane. Under normal conditions, it tightly regulates the movement of ions, proteins, and solutes between the bloodstream and brain parenchyma. When this barrier loses...
Ascites01:19

Ascites

DefinitionAscites is the buildup of fluid inside the peritoneal cavity. It occurs when fluid moves out of the vascular system faster than the peritoneal lymphatics can remove it. This fluid shift is most commonly seen in liver cirrhosis but can also appear in several other systemic disorders.EtiologyCirrhosis remains the leading cause of ascites. Other conditions that can contribute include:Heart failureConstrictive pericarditisAbdominal cancersNephrotic syndromeSevere protein–calorie...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Vasopressin type-2 receptor mRNA expressions in endolymphatic sac and temporal bone cT findings in Meniere's disease.

Acta oto-laryngologica·2026
Same author

Rotational laxity at 30° of knee flexion is associated with postoperative clinical outcomes after bi-cruciate stabilized total knee arthroplasty.

The Knee·2026
Same author

Deep learning approach to super-resolution correction of brain MRI motion artifacts for accurate hippocampal volumetry.

Scientific reports·2026
Same author

Criterion-Related Validity of the Neuropsychological Quick Assessment for Screening Cognitive, Motor, and Behavioral Impairments in Patients With Pediatric Brain Tumors: An Observational Pilot Study.

Pediatric blood & cancer·2026
Same author

Correction: The effect of weight-bearing status on kinematics and cruciate ligament force in normal knees.

Scientific reports·2026
Same author

HMGA2 expression in CIC-rearranged sarcoma and other small round/epithelioid cell tumours.

Histopathology·2026

Related Experiment Video

Updated: Jul 7, 2026

Surgical Induction of Endolymphatic Hydrops by Obliteration of the Endolymphatic Duct
11:49

Surgical Induction of Endolymphatic Hydrops by Obliteration of the Endolymphatic Duct

Published on: January 22, 2010

Decrease in atmospheric pressure could increase endolymphatic space volume in Meniere's disease.

Masaharu Sakagami1, Tadashi Kitahara2, Tadao Okayasu2

  • 1Department of Otolaryngology- Head and Neck Surgery, Nara Medical University, 840 Shijo-cho, Kashihara, Nara, 634-8522, Japan. m.sakagami@naramed-u.ac.jp.

Scientific Reports
|March 29, 2025
PubMed
Summary

Changes in atmospheric pressure may worsen Meniere

Keywords:
Atmospheric pressureEndolymphatic hydropsGadoliniumInner ear MRIMeniere’s diseaseWeather

More Related Videos

Endolymphatic Duct Blockage as a Surgical Treatment Option for Ménière's Disease
04:11

Endolymphatic Duct Blockage as a Surgical Treatment Option for Ménière's Disease

Published on: April 28, 2023

Surgical Treatment of an Endolymphatic Sac Tumor
04:34

Surgical Treatment of an Endolymphatic Sac Tumor

Published on: May 26, 2023

Related Experiment Videos

Last Updated: Jul 7, 2026

Surgical Induction of Endolymphatic Hydrops by Obliteration of the Endolymphatic Duct
11:49

Surgical Induction of Endolymphatic Hydrops by Obliteration of the Endolymphatic Duct

Published on: January 22, 2010

Endolymphatic Duct Blockage as a Surgical Treatment Option for Ménière's Disease
04:11

Endolymphatic Duct Blockage as a Surgical Treatment Option for Ménière's Disease

Published on: April 28, 2023

Surgical Treatment of an Endolymphatic Sac Tumor
04:34

Surgical Treatment of an Endolymphatic Sac Tumor

Published on: May 26, 2023

Area of Science:

  • Otolaryngology
  • Neurology
  • Environmental Medicine

Background:

  • Meniere's disease (MD) is characterized by vertiginous symptoms, potentially linked to endolymphatic hydrops (EH).
  • The connection between EH and meteorological changes remains unclear.
  • Endolymphatic space (ELS) volume can be quantified using 3-Tesla MRI with gadolinium enhancement.

Purpose of the Study:

  • To investigate the correlation between 24-hour atmospheric pressure changes and Endolymphatic Space (ELS) volume in patients with unilateral Meniere's disease (uMD).
  • To compare these correlations in uMD patients versus a control group with chronic rhinosinusitis.
  • To determine if atmospheric pressure fluctuations influence ELS volume in Meniere's disease.

Main Methods:

  • Utilized 3-Tesla MRI with gadolinium enhancement for three-dimensional analysis of ELS volume.
  • Collected atmospheric pressure data from the Japan Meteorological Agency (JMA) for the 24 hours preceding MRI scans.
  • Correlated atmospheric pressure changes with ELS rates in uMD patients and a control group.

Main Results:

  • No significant correlation was observed between atmospheric pressure change and ELS rate in the control group or on the healthy side of uMD patients.
  • A significant negative correlation was found between atmospheric pressure change and vestibular ELS rate on the affected side in uMD patients with moderate hearing impairment (40-70 dB hearing level).

Conclusions:

  • Negative atmospheric pressure changes may impact vestibular Endolymphatic Space (ELS) volume in Meniere's disease patients with moderate hearing loss.
  • This finding suggests a potential environmental trigger for symptom exacerbation in Meniere's disease.
  • Further research is needed to fully elucidate the relationship between weather patterns and Meniere's disease pathophysiology.