Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Long-term Depression01:05

Long-term Depression

27.3K
Long-term depression, or LTD, is one of the ways by which synaptic plasticity—changes in the strength of chemical synapses—can occur in the brain. LTD is the process of synaptic weakening that occurs over time between pre and postsynaptic neuronal connections. The synaptic weakening of LTD works in opposition to synaptic strengthening by long-term potentiation (LTP) and together are the main mechanisms that underlie learning and memory.
27.3K
Longitudinal Research02:20

Longitudinal Research

11.7K
Sometimes we want to see how people change over time, as in studies of human development and lifespan. When we test the same group of individuals repeatedly over an extended period of time, we are conducting longitudinal research. Longitudinal research is a research design in which data-gathering is administered repeatedly over an extended period of time. For example, we may survey a group of individuals about their dietary habits at age 20, retest them a decade later at age 30, and then again...
11.7K
Long-term Depression01:03

Long-term Depression

2.6K
Long-term depression, or LTD, is one of the ways by which synaptic plasticity—changes in the strength of chemical synapses—can occur in the brain. LTD is the process of synaptic weakening that occurs over time between pre and postsynaptic neuronal connections. The synaptic weakening of LTD works in opposition to synaptic strengthening by long-term potentiation (LTP) and together are the main mechanisms that underlie learning and memory.
Calcium Ion Concentration Mechanism
If over...
2.6K
Longitudinal Studies01:26

Longitudinal Studies

706
Longitudinal studies are also widely used in other medical and social science fields. For instance, in cardiovascular research, they can monitor patients' health over decades to identify risk factors for heart disease, such as high cholesterol or smoking, and evaluate the long-term effectiveness of preventive measures. Similarly, in mental health studies, researchers might follow individuals from adolescence into adulthood to understand the development and progression of conditions like...
706
Cognitive Development During Adulthood01:30

Cognitive Development During Adulthood

1.4K
Cognitive development continues throughout adulthood, undergoing significant shifts across early, middle, and late stages. Individual transition occurs from adolescent idealism to pragmatic and adaptable thinking in early adulthood. During this period, individuals learn to integrate personal beliefs with the recognition that other perspectives are equally valid. Exposure to the complexities of modern society, diverse experiences, and higher education contribute to this adaptive thought process,...
1.4K
Negative and Cognitive Symptoms of Schizophrenia01:30

Negative and Cognitive Symptoms of Schizophrenia

1.1K
Negative symptoms of schizophrenia indicate a reduction or absence of typical behaviors and emotional responses found in healthy individuals, while positive symptoms reflect an excess or distortion of normal functioning.
Negative Symptoms
Negative symptoms of schizophrenia manifest as deficits in normal emotional and behavioral functioning, profoundly impacting daily life. Individuals with schizophrenia often display a flat affect, characterized by a near-total absence of emotional expression,...
1.1K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

How loneliness and social isolation are linked to cognitive decline among older adults? A systematic review of underlying physiological and psychobehavioral mechanisms.

Alzheimer's & dementia : the journal of the Alzheimer's Association·2026
Same author

The Mediating Role of Daily Affect Dynamics in Bidirectional and Longitudinal Associations between Depressive Symptoms and Inflammation.

Biopsychosocial science and medicine·2026
Same author

Daily closeness discrepancies and marital interaction quality in the context of chronic pain: mediating effect of loneliness.

The Gerontologist·2026
Same author

Plasma biomarkers of neurodegeneration and their associations with type 1 diabetes characteristics and glycemia.

Diabetes research and clinical practice·2026
Same author

Oxylipin composition of high-density lipoprotein is altered in men and Hispanic adults with mild cognitive impairment.

Journal of lipid research·2026
Same author

Characteristics of discrimination and ambulatory cognitive performance among older Black and White adults.

Current psychology (New Brunswick, N.J.)·2026
Same journal

Urban-rural dichotomy of emergency medical service demand: spatiotemporal patterns and heterogeneous driving mechanisms.

BMC public health·2026
Same journal

Association between household food insecurity and quality of life: a longitudinal study in Northeast Brazil, 2014-2019.

BMC public health·2026
Same journal

Self-medication before and during the COVID-19 pandemic in Türkiye: evidence from national health surveys.

BMC public health·2026
Same journal

Bridging systems for health equity: a scoping review of municipal-public health partnerships.

BMC public health·2026
Same journal

Perceptions of the use of smartwatches for the early detection of cardiac arrhythmias in Saudi Arabia: a cross-sectional study.

BMC public health·2026
Same journal

Maternal metabolic determinants of accelerated infant weight gain in early life: assessing the combined effects of gestational diabetes and pre-pregnancy overweight.

BMC public health·2026
See all related articles

Related Experiment Video

Updated: May 3, 2026

Assessment of Age-related Changes in Cognitive Functions Using EmoCogMeter, a Novel Tablet-computer Based Approach
10:13

Assessment of Age-related Changes in Cognitive Functions Using EmoCogMeter, a Novel Tablet-computer Based Approach

Published on: February 14, 2014

12.4K

Chronic loneliness and longitudinal changes in cognitive functioning.

Jee Eun Kang1, Lynn M Martire2,3, Jennifer E Graham-Engeland2,4

  • 1Center for Healthy Aging, The Pennsylvania State University, Biobehavioral Health Building, University Park, PA, 16802, USA. jxk692@psu.edu.

BMC Public Health
|March 29, 2025
PubMed
Summary
This summary is machine-generated.

Chronic loneliness in young and middle-aged adults hinders cognitive improvement seen in longitudinal studies. Addressing loneliness may prevent cognitive decline and support cognitive health.

Keywords:
Chronic lonelinessCognitionEcological momentary assessmentMeasurement burst designMobile cognitive assessmentProcessing speedSpatial memoryWorking memory

More Related Videos

A Method for Investigating Age-related Differences in the Functional Connectivity of Cognitive Control Networks Associated with Dimensional Change Card Sort Performance
09:01

A Method for Investigating Age-related Differences in the Functional Connectivity of Cognitive Control Networks Associated with Dimensional Change Card Sort Performance

Published on: May 7, 2014

9.5K
Chronic Social Defeat Stress in Early Adolescent Male Mice
07:06

Chronic Social Defeat Stress in Early Adolescent Male Mice

Published on: January 24, 2025

1.8K

Related Experiment Videos

Last Updated: May 3, 2026

Assessment of Age-related Changes in Cognitive Functions Using EmoCogMeter, a Novel Tablet-computer Based Approach
10:13

Assessment of Age-related Changes in Cognitive Functions Using EmoCogMeter, a Novel Tablet-computer Based Approach

Published on: February 14, 2014

12.4K
A Method for Investigating Age-related Differences in the Functional Connectivity of Cognitive Control Networks Associated with Dimensional Change Card Sort Performance
09:01

A Method for Investigating Age-related Differences in the Functional Connectivity of Cognitive Control Networks Associated with Dimensional Change Card Sort Performance

Published on: May 7, 2014

9.5K
Chronic Social Defeat Stress in Early Adolescent Male Mice
07:06

Chronic Social Defeat Stress in Early Adolescent Male Mice

Published on: January 24, 2025

1.8K

Area of Science:

  • Cognitive Neuroscience
  • Psychology
  • Public Health

Background:

  • Loneliness is a global health concern linked to Alzheimer's disease and dementia.
  • Early detection of cognitive changes and risk factors is crucial for cognitive health.
  • This study investigated chronic loneliness as a predictor of cognitive changes in adults aged 25-65.

Purpose of the Study:

  • To examine the association between chronic loneliness and cognitive trajectories.
  • To determine if loneliness impacts working memory, processing speed, and spatial memory over time.
  • To identify potential interventions for mitigating cognitive consequences of loneliness.

Main Methods:

  • Longitudinal study with data collected over two years across three waves.
  • Sample of 172 racially and economically diverse adults (25-65 years).
  • Assessed chronic loneliness using the PROMIS Social Isolation scale and cognitive functions (working memory, processing speed, spatial memory) via mobile assessments. Analyzed data using multilevel growth models.

Main Results:

  • Chronic loneliness did not predict baseline cognitive performance.
  • Loneliness was associated with differential cognitive trajectories, specifically a lack of retest-related improvement.
  • Individuals experiencing chronic loneliness showed no cognitive improvement across waves, unlike their non-lonely counterparts.

Conclusions:

  • Chronically lonely individuals do not exhibit practice-related cognitive improvements observed in longitudinal studies.
  • Findings highlight the importance of early identification and intervention for chronic loneliness.
  • Addressing loneliness may be a key strategy for preventing cognitive decline and supporting cognitive health.