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Prevalence of Pentatrichomonas hominis infection in wild rodents
Yan Tang1, Hai-Tao Wang2,3, Jing-Hao Li4
1College of Pharmacy, Guizhou University of Traditional Chinese Medicine, Guiyang, Guizhou Province, PR China.
Background:
Pentatrichomonas hominis is a zoonotic pathogen linked to gastrointestinal diseases in various animal species and humans. However, its prevalence of in wild rodents remains unexplored. Therefore, investigating the prevalence and molecular characteristics of P. hominis in wild rodents is essential.
Methods:
M. Replace the crossed out sentence above with the following version:This study assessed the prevalence of P. hominis in wild rodents by analyzing 510 fecal samples using nested PCR. Statistical analysis of risk factors was performed with SAS (v9.0) and SPSS software.
Results:
The infection rates were 18.18% (16/88) in Yunnan, 0.94% (3/319) in Hunan, and 0% (0/103) in Guangxi. Among the species, Rattus rattus sladeni had the highest infection rate at 40% (2/5), followed by R. flavipectus at 23.08% (9/39), while Niviventer lotipes (0%, 0/23) and R. losea (0%, 0/41) showed no infection. Seasonally, the highest prevalence was observed in autumn (18.18%, 16/88) and the lowest in winter (0%, 0/103). Rodents from farmland had significantly higher infection rates than mountain areas (0%, 0/103) and lakeshores (0.32%, 1/312). Although female rodents had a higher infection rate (4.62%, 11/238) compared to males (2.94%, 8/272), the difference was not statistically significant. Phylogenetic analysis revealed that all P. hominis strains identified belonged to the zoonotic CC1 genotype.
Conclusions:
This study is the first to describe the distribution of P. hominis in wild rodents, paving the way for further epidemiological research on this parasite in wild animals. Such research is crucial for developing strategies to protect human health from zoonotic threats from wild rodents.
Insights
Pentatrichomonas hominis, a zoonotic parasite, was detected in wild rodents across China. This study identified the zoonotic CC1 genotype, highlighting the need for further research into rodent-borne diseases and human health protection.
Area of Science:
- Veterinary Parasitology
- Zoonotic Disease Epidemiology
- Wildlife Health
Background:
- Pentatrichomonas hominis is a known zoonotic pathogen causing gastrointestinal issues in animals and humans.
- The prevalence and molecular characteristics of P. hominis in wild rodents remain largely uninvestigated.
- Understanding P. hominis in wildlife is crucial for public health and disease control.
Purpose of the Study:
- To determine the prevalence of Pentatrichomonas hominis in wild rodent populations.
- To characterize the molecular features of P. hominis strains found in wild rodents.
- To assess potential risk factors associated with P. hominis infection in wild rodents.
Main Methods:
- Analysis of 510 wild rodent fecal samples using nested PCR to detect P. hominis DNA.
- Statistical analysis of prevalence data and risk factors using SAS and SPSS software.
- Phylogenetic analysis to determine the genetic lineage of identified P. hominis strains.
Main Results:
- P. hominis was detected in Yunnan (18.18%) and Hunan (0.94%), but not in Guangxi.
- Rattus rattus sladeni (40%) and R. flavipectus (23.08%) showed the highest infection rates.
- Farmland environments and autumn season were associated with higher prevalence; all identified strains belonged to the zoonotic CC1 genotype.
Conclusions:
- This study provides the first report on the distribution of P. hominis in wild rodents in China.
- Findings underscore the importance of wild rodents as potential reservoirs for zoonotic P. hominis.
- Further epidemiological studies are essential for developing effective strategies against rodent-borne zoonotic diseases.
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