Purification, characterization and protective effects on UVB-induced photoaging in zebrafish of Pleurotus citrinopileatus polysaccharide PCP-2
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Summary
This summary is machine-generated.A novel polysaccharide, PCP-2, from Pleurotus citrinopileatus effectively combats UVB-induced photoaging. It protects skin by activating the Nrf2/HO-1 pathway, reducing oxidative stress and collagen degradation.
Area Of Science
- Biochemistry
- Dermatology
- Pharmacology
Background
- Pleurotus citrinopileatus polysaccharides possess bioactivities.
- UVB radiation causes skin photoaging.
- The anti-photoaging effects of P. citrinopileatus polysaccharides are unknown.
Purpose Of The Study
- Isolate and characterize a polysaccharide from P. citrinopileatus.
- Evaluate its protective effects against UVB-induced photoaging in a zebrafish model.
- Elucidate the underlying molecular mechanisms.
Main Methods
- Hot-water extraction, ultrafiltration, and chromatography were used for isolation.
- A UVB-induced zebrafish model was employed for efficacy assessment.
- Key molecular pathways, including Nrf2/HO-1, were investigated.
Main Results
- PCP-2, a galactoglucan, demonstrated significant antioxidant, anti-apoptotic, and anti-senescence properties.
- It promoted collagen synthesis by inhibiting MMPs and reduced melanin via tyrosinase downregulation.
- Activation of the Nrf2/HO-1 signaling pathway was identified as the primary mechanism.
Conclusions
- PCP-2 effectively mitigates UVB-induced photoaging.
- The Nrf2/HO-1 pathway is crucial for PCP-2's anti-photoaging effects.
- PCP-2 shows potential as an anti-photoaging agent for food and pharmaceutical applications.
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