Related Experiment Video
Updated: May 9, 2026

Biological Compatibility Profile on Biomaterials for Bone Regeneration
Published on: November 16, 2018
Calcium Sulfate Bone Substitutes in Clinical Use: History, Material Properties, Application, and Outlook for the
Josina Straub1, Andreas Sewing2, Nike Walter1
1Department for Trauma Surgery, University Hospital Regensburg, Regensburg, Germany.
None:
Calcium sulfate-based materials have been used in medicine since the 19th century. Their application makes a significant part in the field of bone regeneration in biomedical engineering. Calcium sulfate is a versatile product that is used not only in the reconstruction of bone defects but also as an antibiotic carrier. Various types of calcium sulfate-based bone grafts have demonstrated their safety, well-tolerance, biodegradability, and osteoconductive properties, making them a potential substitute for autogenous bone transplant in the treatment of bone defects. Calcium sulfate and different-sized calcium sulfate beads can be produced and loaded with different antimicrobial substances. High concentrations of antimicrobial agents can be obtained by applying these locally to affected tissue. This review aims to (1) highlight the development and milestones already achieved in the use of calcium sulfate products and (2) outline the material properties and application areas with their related advantages and disadvantages of calcium sulfate products. Lastly, (3) an outlook for the future of calcium sulfate-based biomaterials is given.
Related Concept Videos
Bone Remodeling
The Bone Matrix
Bone Disorders
Bone deposition is also affected by the levels of sex hormones like estrogen and testosterone that promote osteoblast activity and bone matrix synthesis. When the level of these hormones decreases due to aging, it causes a reduction in bone deposition. As a result, bone resorption by osteoclasts...
Essential Minerals for Bone Health
Calcium and Phosphorus
Calcium is a critical component of bones, especially in the form of calcium phosphate and calcium carbonate. Since the body cannot make calcium, it must be obtained from the diet. However, calcium cannot be absorbed from the small intestine without...
Bone Remodeling and Repair
Bone Marrow Sampling and Transplants
The transplant begins with high doses of chemotherapy and radiation treatment, which aim to destroy the...

