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Updated: Jun 17, 2026

Microfluidic Flow Chambers Using Reconstituted Blood to Model Hemostasis and Platelet Transfusion In Vitro
Published on: March 19, 2016
Consensus instability equations for routine coagulation tests
Rubén Gómez Rioja1, Andrea Caballero Garralda2, Immaculada Comas Reixach2
1Hematology Department, La Paz-Cantoblanco-Carlos III Hospital, Madrid, Spain.
Plasma sample stability for coagulation tests like prothrombin time (PT) and activated partial thromboplastin time (aPTT) is crucial. New consensus instability equations reveal degradation rates, aiding accurate clinical laboratory testing.
Area of Science:
- Clinical Chemistry
- Hematology
- Laboratory Medicine
Background:
- Plasma sample stability for prothrombin time (PT) and activated partial thromboplastin time (aPTT) is critical for accurate coagulation testing.
- Recent updates by the Clinical and Laboratory Standards Institute (CLSI) extended acceptable timeframes for aPTT, necessitating updated stability data.
- Existing guidelines rely on studies with varying maximum permissible error (MPE) criteria, highlighting the need for a unified approach.
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