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Role of SNHGs in Adverse Prognostic Factors in Cervical Cancer: A Systematic Review
Eleilde Almeida Araujo1, Fernanda Jeniffer Lindoso Lima1, Maria Do Socorro De Sousa Cartagenes2
1Postgraduate Program in Adult Health, Federal University of Maranhão, São Luís, Maranhão, Brazil.
Objective:
This study aims to summarize the main findings in the literature regarding the family of long non-coding RNAs (LncRNAs), specifically SNHGs, in cervical cancer.
Methods:
The study was conducted following the PRISMA protocol, using the PICOS framework for the search strategy. The research sources included PubMed, ScienceDirect, Lilacs, and Medline. Inclusion and exclusion criteria were applied, and data from each article were extracted, including: clinicopathological characteristics, biological function of SNHGs, clinical indicators, and diagnostic and prognostic markers.
Results:
Out of a total of 3.803 studies, 12 were selected, encompassing 8 SNHGs (GAS5, SNHG5, SNHG7, SNHG12, SNHG14, SNHG16, SNHG17, and SNHG20) associated with cervical cancer. All, except for GAS5, showed increased expression. In the literature review, SNHG expression was linked to adverse prognostic factors in cervical cancer, such as proliferation, migration, invasion, lymph node metastasis, and apoptosis.
Conclusion:
Although further studies are needed, these data highlight the significant role of SNHGs in tumor biology and the promising potential of this class of transcripts as tools in the clinical management of cervical cancer.
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