PTEN and HES1 Gene Expression Alteration in Breast Cancer: Any Association with Tumor Histomorphological Features or Invasive Behavior?
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View abstract on PubMed
Summary
This summary is machine-generated.Reduced PTEN expression was seen in older breast cancer patients, while HES1 was elevated in most. However, these gene alterations did not reliably predict tumor aggressiveness in this study.
Area Of Science
- Oncology
- Molecular Biology
- Genetics
Background
- Genomic, epigenetic, and proteomic alterations aid in predicting breast tumor behavior.
- Previous studies show conflicting results on the association between PTEN/HES1 gene expression and tumor aggressiveness.
Purpose Of The Study
- To evaluate PTEN and HES1 gene expression in breast cancer.
- To explore the relationship between PTEN/HES1 expression and tumor morphology and behavior.
Main Methods
- Cross-sectional study of 50 women with breast cancer.
- Real-Time PCR used to assess PTEN and HES1 gene expression in tumor and adjacent normal tissues.
- Statistical analysis performed using SPSS, with significance at p ≤ 0.05.
Main Results
- PTEN down-regulation observed in 70% of cases; HES1 up-regulation in 98%.
- PTEN down-regulation associated with higher patient age (p = 0.003).
- HES1 expression showed no significant relationship with histopathological features or invasive behavior.
Conclusions
- Older patients exhibited reduced PTEN expression.
- Elevated HES1 and reduced PTEN were common but did not reliably predict aggressive breast cancer behavior.
- Further research with larger sample sizes and long-term follow-up is needed to confirm prognostic significance.
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