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Multiple gingival recession coverage using indigenously prepared amnion-chorion membrane: a clinical study.
Supriya Jain1, Arundeep Kaur Lamba2, Farrukh Faraz2
1Department of Periodontology, Maulana Azad Institute of Dental Sciences, New Delhi, 110002, India. supriya89jain@gmail.com.
Cell and Tissue Banking
|March 29, 2025
Summary
This study shows that using amnion-chorion membrane with the Zucchelli technique effectively treats gingival recession, achieving significant root coverage and improving gum tissue health.
Area of Science:
- Periodontology
- Regenerative Medicine
- Biomaterials Science
Background:
- Gingival recession is a common condition affecting oral health.
- Effective management of multiple adjacent gingival recession remains a clinical challenge.
- Amnion-chorion membrane (ACM) shows potential as a regenerative biomaterial.
Purpose of the Study:
- To evaluate the efficacy of an indigenously prepared amnion-chorion membrane (ACM) for managing multiple adjacent gingival recession.
- To assess root coverage and changes in keratinized tissue dimensions using ACM.
- To determine the clinical outcomes of ACM in conjunction with the Zucchelli technique.
Main Methods:
- A prospective clinical study involving 15 healthy subjects (8 female, 7 male; age 18-55).
- Treatment involved the Zucchelli technique combined with the placement of ACM for maxillary anterior and premolar gingival recession defects.
- Clinical examinations were performed post-surgery to assess outcomes.
Main Results:
- Complete root coverage was achieved in 44 out of 52 treated sites (97.77% mean root coverage).
- Significant increases in the width and thickness of keratinized tissue were observed (p < 0.01).
- Post-surgical gingival tissues exhibited healthy color and texture, blending with adjacent tissues.
Conclusions:
- Indigenously prepared amnion-chorion membrane, when used with the Zucchelli technique, is effective for managing multiple adjacent gingival recession.
- ACM promotes significant root coverage and enhances keratinized tissue dimensions.
- Further long-term, multicentric, randomized controlled trials are recommended to validate these findings and explore ACM's broader potential in regenerative periodontics.
