Double low protocol in pediatric abdominal CT for evaluating right lower quadrant pain

In pediatric patients, minimizing radiation and contrast media exposure without compromising diagnostic accuracy is paramount. Double low protocol, which utilizes a low dose contrast concentration and low tube voltage, could be a safer alternative. We compare diagnostic efficacy of double low protocol (Group A, 240 mgI/ml + 80 kVp) with conventional protocol (Group B, 350 mgI/ml + 120 kVp) in pediatric patients (< 10 years) presenting with abdominal pain and suspected acute appendicitis.

This retrospective study included 121 pediatric patients who underwent enhanced abdominal CT between January 2019 and February 2023: 62 with Group A and 59 with Group B. We compared radiation dose, iodine load, and quantitative image quality parameters. Two radiologists independently assessed diagnostic image quality on a 5-point scale, visualization of the appendix, and diagnostic performance for acute appendicitis and its complications.

There were no significant differences in mean age (7.6 ± 2.0 vs. 7.6 ± 2.1, p = 0.956), body weight (31.4 ± 11.2 kg vs. 31.7 ± 11.4 kg, p = 0.972), and contrast media volume used (59.3 ± 21.0 ml vs. 65.0 ± 20.0 ml, p = 135) between the two groups. However, effective dose and iodine load used were significantly lower in Group A compared to Group B (2.7 ± 1.1 mSv vs. 4.3 ± 1.5 mSv and vs. 12.7 ± 4.6gI vs.18.6 ± 6.7gI, all p < 0.001). Although diagnostic image quality, noise and signal-to-noise ratio were significantly lower in Group A, visualization of the appendix (p = 0.853) and diagnostic accuracy for appendicitis were comparable between the two groups (98.4% vs. 94.9%, p = 0.284).

The double low protocol offers an effective alternative for evaluating pediatric patients requiring enhanced abdomen CT, achieving comparable diagnostic performance while significantly reducing radiation dose. We believe that our findings support safer CT acquisition practices for pediatric patients requiring enhanced CT imaging.