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Factors influencing acceptance of RSV immunization for newborns among pregnant individuals: A mixed-methods study

Dominique Gagnon1, Charlotte Gubany2, Manale Ouakki1

  • 1Direction des risques biologiques, Institut national de santé publique du Québec, 945 Av. Wolfe, Québec (Québec), G1V 5B3, Canada.

Vaccine
|March 29, 2025
PubMed

Insights

Pregnant individuals show high interest in new respiratory syncytial virus (RSV) immunizations for infants. Key factors for acceptance include vaccine safety, efficacy, and healthcare provider recommendations, crucial for preventing infant hospitalizations.

Area of Science:

  • Public Health
  • Immunology
  • Maternal-Fetal Medicine

Background:

  • Respiratory syncytial virus (RSV) is a significant cause of infant respiratory illness and hospitalization in Canada.
  • Health Canada has approved two new preventative measures: a maternal vaccine and an infant monoclonal antibody.
  • Understanding pregnant individuals' perspectives on these novel RSV prevention methods is essential.

Purpose of the Study:

  • To assess knowledge, attitudes, and intentions of pregnant individuals regarding RSV and its prevention.
  • To explore decision-making factors and preferences for maternal vaccination versus infant monoclonal antibodies.
  • To identify barriers and facilitators for uptake of new RSV immunizing products.

Main Methods:

  • A mixed-methods study conducted in Quebec, Canada (October-December 2023).
  • Online survey (n=803) assessing RSV knowledge, attitudes, and intentions towards immunization products.
  • Qualitative interviews (n=25) exploring decision-making factors and preferences for RSV prevention.

Main Results:

  • High intention for both RSV maternal vaccination (88.1%) and infant monoclonal antibodies (92%).
  • Majority preferred maternal vaccination (69%) over infant antibodies.
  • Key acceptance factors included infant protection, product safety, efficacy, and healthcare provider recommendations; safety concerns were also noted.

Conclusions:

  • Pregnant individuals express strong interest in both maternal vaccination and infant monoclonal antibodies for RSV prevention.
  • Healthcare provider recommendations and clear information on safety and efficacy are critical for successful implementation.
  • Bridging the gap between intention and action requires addressing parental concerns and providing evidence-based guidance.
Abstract

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