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Constructing a blood contact material surface with selective adhesion of multiple cells using TiO2 photocatalytic
Luying Liu1, Peng Ye2, Jingmei Pan2
1Shandong Provincial Engineering Research Center of Novel Pharmaceutical Excipients and Controlled Release Preparations, College of Pharmacy, Dezhou University, Dezhou 253023, PR China; Institute of Biomedical Engineering, College of Medicine, Southwest Jiaotong University, Chengdu 610031, PR China.
Abstract:
The effective measure to promoting endothelial repair is to construct a surface similar to that of normal vascular on blood contact materials. The construction of cell culture platform regulating platelets, endothelial cells (ECs) and Smooth muscle cells (SMCs) may provide more help to promote endothelial repair. In this work, a novel versatile cell research platform UV-P-PDA@TiO2 was constructed by magnetron sputtering and photoetching. The surface of UV-P-PDA@TiO2 was evaluated by materials science methods such as FTIR, Raman, Micro BCA and WCA, and cell culture was performed on the surface. These results indicated that UV-P-PDA@TiO2 platform regulated the cellular behavior of platelets, ECs, and SMCs, achieved selective adhesion, and exhibited orientation. The advantage of histocompatibility was demonstrated by in vivo tests that UV-P-PDA@TiO2 had pattern stability and inhibited tissue proliferation. Conceivably, the regulating the multicellular UV-P-PDA @ TiO2 culture platform may provide a versatile surface engineering strategy for biomaterials.
