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Updated: Jul 10, 2026
05:06
Bioluminescent Bacterial Imaging In Vivo
Published on: November 4, 2012
Metabolic reprogramming of tumor microenviroment by engineered bacteria
Heng Wang1, Fang Xu1, Chao Wang1
1Laboratory for Biomaterial and Immunoengineering, Institute of Functional Nano & Soft Materials (FUNSOM), Soochow University, Suzhou, Jiangsu 215123, China.
Seminars in Cancer Biology
|March 29, 2025
Summary
Engineered bacteria can reprogram tumor microenvironment (TME) metabolism to enhance cancer immunotherapy. This approach modulates the TME to improve antitumor immunity and therapeutic responses.
Area of Science:
- Oncology
- Immunology
- Metabolic Engineering
Background:
- The tumor microenvironment (TME) is critical for tumor progression and therapeutic response.
- Metabolic reprogramming in cancer cells is key for proliferation, survival, and immune evasion.
- Engineered bacteria offer a novel strategy to modulate TME metabolism for cancer immunotherapy.
Purpose of the Study:
- To review the metabolic properties and adaptations within the TME.
- To summarize strategies of engineered bacteria in regulating tumor metabolism.
- To discuss the potential of engineered bacteria in overcoming immunosuppressive TME for improved antitumor therapy.
Main Methods:
- Review of current literature on TME metabolism and engineered bacteria.
- Analysis of metabolic reprogramming in tumor and immune cells.
- Examination of engineered bacterial strategies for TME modulation.
Main Results:
- TME metabolism significantly influences cancer cell behavior and immune response.
- Engineered bacteria can reprogram TME metabolism to enhance antitumor immunity.
- Metabolic reprogramming by engineered bacteria can overcome TME-mediated immunosuppression.
Conclusions:
- Engineered bacteria represent a promising approach to reshape TME metabolism.
- This strategy holds potential for improving the efficacy of cancer immunotherapy.
- Further research is needed to address challenges and facilitate clinical translation.
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