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Determination of long-range resistance from high resolution impedance spectroscopy in human cadaveric heads.

Zeitschrift fur medizinische Physik·2026
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A Data-Driven Visit Windowing Approach Applied to Cochlear Implant Follow-Up Data.

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Functional hearing and low frequency hearing preservation after cochlear implant surgery is achievable with FLEX electrode arrays: Real world evidence from the MEHS Registry.

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Dexamethasone abolishes intra-day fluctuations of electrode impedance in cochlear implant users.

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Related Experiment Video

Updated: Jul 6, 2026

Performing Intracochlear Electrocochleography During Cochlear Implantation
09:10

Performing Intracochlear Electrocochleography During Cochlear Implantation

Published on: March 8, 2022

Cochlear implantation with a dexamethasone-eluting electrode array: First-in-human safety and performance results.

Nils Prenzler1, Rolf Salcher1, Andreas Büchner1

  • 1Department of Otorhinolaryngology, Hannover Medical School, Hannover, Germany.

Hearing Research
|March 30, 2025
PubMed
Summary

The CIDEXEL system, combining a cochlear implant with a dexamethasone-eluting electrode array, shows promising safety and hearing preservation in a first-in-human study for severe hearing loss.

Keywords:
Cochlear implantDexamethasoneElectrode arrayFeasibility studyHearing preservationInflammation

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Enhanced Cochlear Coverage and Hearing Preservation in High-Frequency Hearing Loss via Electric Acoustic Stimulation with Longer Electrode
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Enhanced Cochlear Coverage and Hearing Preservation in High-Frequency Hearing Loss via Electric Acoustic Stimulation with Longer Electrode

Published on: October 11, 2024

Related Experiment Videos

Last Updated: Jul 6, 2026

Performing Intracochlear Electrocochleography During Cochlear Implantation
09:10

Performing Intracochlear Electrocochleography During Cochlear Implantation

Published on: March 8, 2022

Subdural Soft Electrocorticography (ECoG) Array Implantation and Long-Term Cortical Recording in Minipigs
08:30

Subdural Soft Electrocorticography (ECoG) Array Implantation and Long-Term Cortical Recording in Minipigs

Published on: March 31, 2023

Enhanced Cochlear Coverage and Hearing Preservation in High-Frequency Hearing Loss via Electric Acoustic Stimulation with Longer Electrode
03:49

Enhanced Cochlear Coverage and Hearing Preservation in High-Frequency Hearing Loss via Electric Acoustic Stimulation with Longer Electrode

Published on: October 11, 2024

Area of Science:

  • Otorhinolaryngology
  • Biomedical Engineering
  • Neuroscience

Background:

  • Cochlear implantation is standard for severe-to-profound sensorineural hearing loss.
  • Implantation can cause hearing loss due to trauma and inflammation.
  • Sustained local drug delivery from electrode arrays may preserve residual hearing.

Purpose of the Study:

  • Evaluate the safety and feasibility of the CIDEXEL system (Mi1200 SYNCHRONY CI with FLEX28 DEX array).
  • Assess electrode impedance, hearing preservation, and speech perception.
  • Gather surgeon feedback on intraoperative handling.

Main Methods:

  • Single-arm, exploratory, open-label, prospective, longitudinal, monocentric study.
  • Nine participants received the CIDEXEL system.
  • Follow-up up to 9 months post-implantation.

Main Results:

  • No device- or procedure-related serious adverse events occurred.
  • Low and stable electrode impedance levels were maintained.
  • Good residual hearing preservation (≤15 dB loss) in most participants.
  • Speech perception outcomes were comparable to non-eluting arrays.
  • Surgeons reported similar handling and insertion to conventional arrays.

Conclusions:

  • The CIDEXEL system is safe and feasible for cochlear implantation.
  • It effectively preserves residual hearing and provides good speech perception.
  • The device demonstrates comparable surgical handling to standard electrode arrays.