Related Experiment Video
Updated: Oct 2, 2026

A Model of Chronic Nutrient Infusion in the Rat
Published on: August 14, 2013
Phosphatidylinositol composition in pancreas and submaxillary gland of ethanol-fed rats
Abstract:
The possibility that changes in the stimulus-secretion coupling are involved in the etiology of pancreatitis was investigated by analysis of the molecular composition of the phosphatidylinositols in pancreas of rats fed a liquid ethanol-containing diet and pair-fed controls. The arachidonoyl-containing phosphatidylinositols were about half as abundant in the ethanol-fed rats. Opposite differences were seen for the major species containing linoleoyl, oleoyl or stearoyl groups at C-2. Ethanol-induced lipid peroxidation did not seem to be involved, since carbon tetrachloride administration had no effect on the composition. In the submaxillary gland, that has a similar stimulus-secretion coupling, the arachidonoyl-containing phosphatidylinositols constituted about a 25% smaller fraction in the ethanol-fed rats. Dexamethasone administration did not change the effect. Possibly, decreased secretory response in these glands in ethanol-fed rats is caused by the change in phosphatidylinositol composition.
Related Concept Videos
Phosphoinositides and PIPs
Different phosphoinositides are synthesized and recruited on the cytosolic face of the plasma membrane. The localization of specific phosphoinositides concentrated in separate membrane...
Insulin Secretory Vesicles
Chronic Pancreatitis I: Introduction
Pancreatitis is the inflammation of the pancreas, which occurs when the immune system becomes active and causes swelling, pain, and disruptions in organ function. Pancreatitis can manifest as either an acute or chronic condition.
Acute pancreatitis arises suddenly and lasts for a brief duration, while chronic pancreatitis is a long-term affliction...
Glucose Homeostasis: Pancreatic Islets and Insulin Secretion
Insulin and C-peptide are co-secreted in...
Insulin: Biosynthesis, Chemistry, and Preparation
Damage or functional impairment of β-cells inhibits insulin production, leading to diabetes. Diabetes treatment primarily uses...
Chronic Pancreatitis II: Pathophysiology

