Green synthesized (Curcuma longa) Ni nanoparticles doped chitosan and PEG for wound healing and anti-bacterial...

The development of advanced wound dressings with enhanced absorption capacity and reduced adhesion is critical for effective wound management. This study presents a novel approach utilizing nickel (Ni) nanoparticles synthesized using curcumin extracted from Curcuma longa, known for its wound healing and antimicrobial properties. The Ni nanoparticles were incorporated with chitosan and polyethylene glycol (PEG) to form cross-linked nanocomposites with improved absorptive and mechanical properties. The wound healing potential was assessed through histopathological analysis, wound contraction rates, and antibacterial activity against Escherichia coli. The results demonstrated accelerated wound closure within 10-12 days, enhanced tissue regeneration, and significant antibacterial efficacy. Structural and compositional analyses, including UV-Visible spectroscopy, FTIR, XRD, Zeta Potential, EDX, and SEM, confirmed the successful synthesis and stability of the nanocomposites. This study highlights the potential of curcumin-loaded nanocomposites (CS-Ni and PEGNi) as a promising wound dressing material, paving the way for nanotechnology-driven innovations in wound care and tissue engineering.