Janus asymmetric galactomannan-based hydrogel with programmable deformation for accelerating wound healing
- Yuyu E 1, Wen Li 2, Pengfei Li 2, Fuhou Lei 2, Xi Yao 3, Shengguang Yuan 4, Jie Li 4, Fenglun Zhang 5, Jianxin Jiang 1, Kun Wang 1
- Yuyu E 1, Wen Li 2, Pengfei Li 2
- 1Department of Chemistry and Chemical Engineering, Beijing Forestry University, MOE Engineering Research Center of Forestry Biomass Materials and Bioenergy, Beijing 100083, China.
- 2Key Laboratory of Chemistry and Engineering of Forest Products, State Ethnic Affairs Commission, Guangxi Key Laboratory of Chemistry and Engineering of Forest Products, Guangxi Collaborative Innovation Center for Chemistry and Engineering of Forest Products, Guangxi Minzu University, Nanning 530006, China.
- 3International Centre for Bamboo and Rattan, Beijing 100020, China.
- 4State Key Laboratory of Environmental Aquatic Chemistry, Research Centre for Eco-Environmental Sciences, Chinese Academy of Sciences, Beijing, China.
- 5Nanjing Institute for the Comprehensive Utilization of Wild Plants, Nanjing 211111, China.
- 0Department of Chemistry and Chemical Engineering, Beijing Forestry University, MOE Engineering Research Center of Forestry Biomass Materials and Bioenergy, Beijing 100083, China.
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View abstract on PubMed
Summary
This summary is machine-generated.This study developed a Janus hydrogel wound dressing that accelerates healing. Its unique thermo-responsive and adhesive properties promote faster wound closure and tissue regeneration.
Area Of Science
- Biomaterials Science
- Regenerative Medicine
- Polymer Chemistry
Background
- Accelerated wound closure is critical for effective clinical treatment.
- Current wound dressings often lack multifunctional properties for optimal healing.
- Asymmetrical engineering of wound dressings offers potential for enhanced therapeutic outcomes.
Purpose Of The Study
- To fabricate a Janus hydrogel wound dressing with thermo-responsive and adhesive properties.
- To evaluate the hydrogel's mechanical, antibacterial, and wound healing capabilities.
- To demonstrate the potential of this novel dressing for sutureless wound repair.
Main Methods
- Fabrication of a Janus hydrogel using isopropylacrylamide, polyacrylamide, zwitterionic monomers, and hyaluronic acid.
- Characterization of hydrogel properties including tensile stress, fracture strain, and tissue adhesiveness.
- In vitro assessment of antibacterial activity and in vivo evaluation of wound healing efficiency.
Main Results
- The hydrogel exhibited high tensile stress (80 Kpa) and fracture strain (3000%).
- Demonstrated significant tissue adhesiveness (35 Kpa) and 99.9% bacterial reduction.
- In vivo studies showed 99% wound healing efficiency by day 14, with enhanced contraction and tissue formation.
Conclusions
- The developed Janus hydrogel is a promising multifunctional wound dressing.
- Its thermo-responsive and adhesive characteristics promote accelerated and sutureless wound closure.
- The hydrogel effectively enhances wound healing by promoting tissue regeneration and collagen deposition.
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