Ten-membered lactones with antifungal activity against the postharvest pathogens from Penicillium restrictum
Jing Sun1, Feng-Shuang Wei1, Tong-De Zhao1
1Yunnan Characteristic Plant Extraction Laboratory, Co., Ltd., Key Laboratory of Medicinal Chemistry for Natural Resource, Ministry of Education, School of Chemical Science and Technology, Yunnan University, Kunming 650500, People's Republic of China.
Abstract:
Two undescribed ten-membered lactones, named penicirestricols A (1) and B (2), and two unprecedented ten-membered lactone-adenine hybrids, penicirestricols C (3) and D (4), along with four known compounds, decarestrictines B (5), A1 (6), F (7), and I (8) were isolated from the endophytic fungus Penicillium restrictum. The structures were determined by 1D, 2D NMR techniques, mass spectrometry, ECD, and NMR calculations. Compounds 3, 7, and 8 from P. restrictum showed significant antifungal activities against postharvest pathogens Fusarium asiaticum and Alternaria tenuissima with MICs ≤8 μg/mL. Thus, the compounds isolated from P. restrictum have the potentiality to be developed as the novel antifungal agents.
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