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Zwitterionic Dipeptide Surface Functionalization of Detonation Nanodiamond for Enhanced Control in Biological
Elisabeth Mayerhoefer1, Himalaya Parajuli2,3, Mihaela-Roxana Cimpan4
1Institute of Organic Chemistry, University of Stuttgart, Pfaffenwaldring 55, 70569, Stuttgart, Germany.
Angewandte Chemie (International Ed. in English)
|March 30, 2025
Summary
Researchers developed zwitterionic dipeptide-modified nanodiamonds (NDs) for improved biocompatibility and stability. These functionalized NDs show promise for various biomedical applications, including drug delivery and biosensing.
Area of Science:
- Biomaterials Science
- Nanomedicine
- Surface Chemistry
Background:
- Nanoparticles (NPs) require controlled properties for safe biomedical use.
- Nanodiamonds (NDs) offer biocompatibility but need stable surface modifications.
- Zwitterionic modifications enhance NP protein repellency and biocompatibility.
Purpose of the Study:
- To develop and characterize zwitterionic dipeptide-functionalized NDs.
- To assess the stability and biocompatibility of modified NDs.
- To investigate the interaction of functionalized NDs with biological systems.
Main Methods:
- Covalent conjugation of zwitterionic dipeptides to nanodiamond surfaces.
- Evaluation of colloidal stability across pH and protein-rich media.
- Assessment of biocompatibility and cellular uptake.
- Ex vivo studies using organotypic models and squamous epithelium.
Main Results:
- Achieved reproducible and tunable functionalization of NDs with zwitterionic dipeptides.
- Demonstrated enhanced colloidal stability and preserved particle size.
- Showed tailored biocompatibility and cellular uptake based on dipeptide choice.
- Revealed specific interactions of functionalized NDs with squamous epithelium.
Conclusions:
- Zwitterionic dipeptide functionalization provides a robust method for enhancing ND properties.
- Functionalized NDs exhibit improved stability and tunable biological interactions.
- These modified NDs are suitable for diverse biomedical applications like biosensing and drug delivery.
