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Relationship between choroidal structure and myocardial collateral flow regulation in acute and chronic coronary

Gurcan Dogukan Arslan1, Levent Dogan2, Zeki Dogan3

  • 1Department of Ophthalmology, Istanbul Medicine Hospital, Goztepe District, 2366th Street, Bagcilar, 34214, Istanbul, Turkey. mr.dogukan2@gmail.com.

International Ophthalmology
|March 30, 2025
PubMed

Insights

Patients with chronic coronary heart disease (CHD) showed lower choroidal vascular index (CVI) and subfoveal choroidal thickness (SFCT). Larger collateral size was linked to reduced CVI and SFCT in chronic CHD.

Area of Science:

  • Ophthalmology
  • Cardiology
  • Vascular Biology

Background:

  • Coronary heart disease (CHD) affects cardiovascular health.
  • Coronary collateral circulation plays a role in myocardial ischemia.
  • Choroidal parameters may reflect systemic vascular health.

Purpose of the Study:

  • To investigate the relationship between coronary collateral parameters and choroidal characteristics.
  • To compare these parameters in patients with acute and chronic CHD versus healthy controls.

Main Methods:

  • Observational cross-sectional study including 38 acute CHD, 38 chronic CHD, and 32 control participants.
  • Coronary collateral filling scored using diagnostic coronary angiograms.
  • Choroidal vascular index (CVI) and subfoveal choroidal thickness (SFCT) measured in CHD patients.

Main Results:

  • Chronic CHD patients exhibited significantly lower CVI and SFCT compared to acute CHD and control groups.
  • In chronic CHD, collateral size was significantly associated with reduced CVI and SFCT.
  • No significant associations were found between choroidal parameters, collateral size, and filling in acute CHD.

Conclusions:

  • Lower CVI and SFCT in chronic CHD may indicate chronic myocardial ischemia.
  • A potential link exists between larger coronary collateral size and diminished CVI/SFCT in chronic CHD.
  • This association might be influenced by reduced angiogenic factors in chronic CHD.
Abstract

Keywords:
ChoroidChoroidal vascular indexCoronary collateralCoronary heart disease

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