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Noninvasive Sampling of Mucosal Lining Fluid for the Quantification of In Vivo Upper Airway Immune-mediator Levels
Published on: August 7, 2017
Dynamic association between plasma interleukin-1 family concentrations and bronchopulmonary dysplasia in extremely
Qingling Li1, Cuihui Li1, Yunbei Rao1
1Department of Neonatology, Shenzhen Maternity and Child Healthcare Hospital, the First School of Clinical Medicine, Southern Medical University, Shenzhen, China.
Insights
Elevated interleukin-1 alpha (IL-1α) levels in extremely preterm infants at postnatal day 28 are linked to a higher risk of developing bronchopulmonary dysplasia (BPD). This finding highlights IL-1α as a potential biomarker for BPD.
Area of Science:
- Neonatal immunology
- Respiratory medicine
- Inflammatory biomarkers
Background:
- Bronchopulmonary dysplasia (BPD) is a significant complication in extremely preterm infants.
- Interleukin-1 (IL-1) cytokines play a role in inflammatory processes relevant to lung development.
Purpose of the Study:
- To examine longitudinal changes in IL-1α, IL-1β, and IL-1 receptor antagonist (IL-1Ra) in extremely preterm infants.
- To investigate the association between these IL-1 cytokines and the development of BPD.
Main Methods:
- Plasma samples were collected from extremely preterm infants at postnatal day 7, 28, and 36 weeks postmenstrual age.
- Interleukin-1 cytokine concentrations were quantified using the Bio-Plex Pro human cytokine panel.
- Univariate and multivariate logistic regression analyses were employed to assess the relationship between cytokine levels and BPD.
Main Results:
- Infants who developed BPD had significantly higher concentrations of IL-1α, IL-1β, and IL-1Ra at postnatal day 28 compared to non-BPD infants.
- Higher IL-1α concentration (≥8.09 pg/ml) at postnatal day 28 was independently associated with an increased risk of BPD development (OR: 8.272, p=0.038).
Conclusions:
- Elevated IL-1α concentrations at postnatal day 28 are independently associated with an increased risk of developing BPD in extremely preterm infants.
- IL-1α may serve as a potential predictive biomarker for BPD in this vulnerable population.
Objective:
To evaluate the longitudinal changes of IL-1α, IL-1β, and IL-1Ra in extremely preterm infants and investigate the dynamic association with bronchopulmonary dysplasia (BPD).
Methods:
Plasma samples were collected from extremely preterm infants at postnatal day (PD) 7,28 and PMA 36 weeks. IL-1 cytokines concentrations were measured by Bio-Plex Pro (human cytokine panel). Univariate and multivariate logistic regression analysis were conducted to explore the association between the cytokines and BPD.
Results:
BPD infants exhibited significantly higher concentrations of IL-1α (10.75 vs. 8.18 pg/ml, p = 0.026), IL-1β (2.00 vs. 1.50 pg/ml, p = 0.046), and IL-1Ra (878.50 vs. 262.40 pg/ml, p = 0.011) compared to non-BPD infants at PD 28. Higher IL-1α concentration (≥8.09 pg/ml) at PD 28 was independently associated with BPD development (OR: 8.272, 95% CI: 1.127-60.705, p = 0.038).
Conclusions:
Increased IL-1α concentrations at PD 28 were independently associated with an increased risk of BPD.
