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Related Concept Videos

Skin Cancer01:30

Skin Cancer

Skin cancer is a type of cancer that occurs when there is an abnormal growth of skin cells, usually triggered by damage to the DNA within the skin cells. It is primarily caused by exposure to ultraviolet (UV) radiation from the sun or artificial sources like tanning beds. Skin cancer is the most common type of cancer worldwide, and its incidence continues to rise.
Basal Cell Carcinoma (BCC): BCC is the most common type of skin cancer, accounting for about 80% of cases. It typically develops in...

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Solitary Morphea Profunda: A Case Report.

S F Sobhan1, M Shafiquzzaman, M R Islam

  • 1Dr Sobnam Faria Sobhan, Registrar, Department of Dermatology and Venereology, Mymensingh Medical College Hospital (MMCH), Mymensingh, Bangladesh;

Mymensingh Medical Journal : MMJ
|March 31, 2025
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Summary
This summary is machine-generated.

Morphea profunda, a deep form of localized scleroderma, presents as sclerotic plaques affecting skin and deeper tissues. Methotrexate effectively treated a 12-year-old girl with this rare autoimmune condition.

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Area of Science:

  • Dermatology
  • Autoimmune Diseases
  • Connective Tissue Disorders

Background:

  • Morphea is an autoimmune disease causing skin and subcutaneous tissue sclerosis due to excess collagen.
  • Morphea profunda affects deep dermis, subcutaneous tissue, fascia, and muscle, presenting as deep sclerotic plaques.
  • Diagnosis relies on clinical appearance, with histopathology crucial for assessing depth and severity.

Purpose of the Study:

  • To present a case of morphea profunda in a pediatric patient.
  • To highlight the diagnostic and management approach for morphea profunda.

Main Methods:

  • Clinical assessment including the LoSCAT (Localized Scleroderma Cutaneous Assessment Tool) scoring system.
  • Confirmation of diagnosis via skin biopsy for histopathology.
  • Treatment with systemic methotrexate.

Main Results:

  • A 12-year-old girl presented with a depressed, hypopigmented lesion on her left arm, showing signs of deep tissue involvement.
  • The LoSCAT score indicated moderate disease activity with significant tissue damage.
  • Histopathology confirmed morphea profunda, and the patient responded to methotrexate treatment.

Conclusions:

  • Morphea profunda requires thorough evaluation, including histopathology, for accurate diagnosis and staging.
  • Systemic methotrexate is a viable treatment option for morphea profunda in pediatric cases.
  • Early diagnosis and appropriate management are crucial for minimizing long-term damage in morphea profunda.