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Human papillomavirus self-sampling in Asia: a systematic review
Xuechao Ji1, Menglin Hao1, Yixiao Wang1
1Department of Gynecologic Oncology, Beijing Obstetrics and Gynecology Hospital, Beijing Maternal and Child Health Care Hospital, Capital Medical University, Beijing, China.
Frontiers in Microbiology
|March 31, 2025
Summary
Human papillomavirus (HPV) self-sampling is an accurate alternative to traditional cervical cancer screening. This method shows high accuracy and acceptance among Asian women, improving screening coverage.
Area of Science:
- Gynecology
- Oncology
- Public Health
Background:
- Cervical cancer screening is crucial for early detection and prevention.
- Human papillomavirus (HPV) testing is a primary method for cervical cancer screening.
- HPV self-sampling offers a potentially effective alternative to clinician-collected samples.
Purpose of the Study:
- To systematically review and compare the accuracy and acceptance of HPV self-sampling versus clinician sampling in Asia.
- To assess the agreement between self- and clinician-collected samples for HPV detection.
- To evaluate women's preferences and concerns regarding HPV self-sampling.
Main Methods:
- A systematic review of studies published up to 2023 from major databases (PubMed, Cochrane, CINAHL, Web of Science).
- Inclusion of studies evaluating HPV self-sampling accuracy, acceptance, and agreement with clinician sampling in Asia.
- Risk of bias assessed using the QUADAS-2 tool; accuracy measured by sensitivity, specificity, and HPV detection rates.
Main Results:
- Sixty-seven studies involving 117,279 participants were analyzed.
- HPV self-sampling demonstrated high accuracy (sensitivity >80%, specificity >70%) comparable to clinician sampling.
- High agreement (kappa >0.7) between self- and clinician-collected samples was observed, with women showing high acceptance but some concerns.
Conclusions:
- HPV self-sampling can significantly increase cervical cancer screening coverage, particularly in resource-limited settings or where physician sampling is less accepted.
- While generally accurate and accepted, adjustments to diagnostic criteria and HPV detection methods may be needed for specific regions like China and India.
- Targeted health education is recommended to further enhance women's acceptance and uptake of HPV self-sampling.
