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Hyaluronate increases intraocular pressure when used in cataract extraction
The British Journal of Ophthalmology
|August 1, 1985
Summary
Sodium hyaluronate temporarily increased intraocular pressure after cataract surgery. Air provided a more stable intraocular pressure, while acetazolamide showed no significant effect on managing eye pressure post-surgery.
Area of Science:
- Ophthalmology
- Surgical Innovation
- Clinical Trials
Background:
- Cataract surgery requires restoring anterior chamber volume.
- Maintaining stable intraocular pressure (IOP) is crucial post-surgery.
- Various agents are used to reform the anterior chamber after cataract extraction.
Purpose of the Study:
- To compare the effects of air, sodium hyaluronate, and sodium hyaluronate with acetazolamide on IOP.
- To evaluate IOP changes following uncomplicated intracapsular cataract surgery.
- To determine the efficacy of different anterior chamber reforming agents.
Main Methods:
- Prospective randomized study involving 26 eyes (24 patients).
- Three groups: air, sodium hyaluronate, and sodium hyaluronate plus acetazolamide.
- Intraocular pressure measured using Goldmann applanation tonometry over 72 hours.
Main Results:
- Sodium hyaluronate significantly increased IOP in the first 24 hours post-surgery.
- Air initially caused a slight decrease in IOP.
- Acetazolamide did not show a statistically significant effect on IOP management.
Conclusions:
- Sodium hyaluronate can cause a transient IOP spike after cataract surgery.
- Air appears to be a safe alternative for anterior chamber reformation.
- Further research may be needed to clarify acetazolamide's role in this context.