A Case of Diffuse B-Cell Lymphoma Presenting as a Rash on the Chest and Abdomen

Diffuse large B-cell lymphoma (DLBCL) can present with skin manifestations either as a primary cutaneous DLBCL or as systemic DLBCL with cutaneous manifestations. The majority of cutaneous cases present with erythematous nodules on the legs, most commonly the lower legs. DLBCL presenting at a cutaneous site can be mistaken for cellulitis, a chronic venous ulcer, or psoriasis. Here, we present a case of DLBCL manifesting as a rash on the upper chest, shoulder, and abdomen. The case is notable in the fact that the rash developed while the patient was hospitalized and being treated for sepsis, with a drug-induced rash being a confounding diagnosis.