Related Experiment Video For age-adjusted d-dimer
Updated: May 5, 2026

Echocardiographic Evaluation of Atrial Communications before Transcatheter Closure
Published on: February 8, 2022
Computed Tomography Pulmonary Angiography (CTPA) Utilization in Suspected Pulmonary Embolism Patients Based on
Ahmed Malik1, Mohammed Ahmed1, Sara Hamid1
1Acute Internal Medicine, University Hospitals of North Midlands NHS Trust, Royal Stoke University Hospital, Stoke-on-Trent, GBR.
Abstract:
Computed tomography pulmonary angiography (CTPA) is the gold standard for diagnosing pulmonary embolism (PE), but its overuse can lead to unnecessary radiation exposure and increased healthcare costs. This clinical audit evaluated adherence to National Institute for Health and Care Excellence (NICE) guidelines (NG 158) for CTPA utilization in suspected PE cases. A retrospective analysis of 164 patients at the Royal Stoke University Hospital assessed the application of the pulmonary embolism rule-out criteria (PERC) score in patients aged 18-49 and age-adjusted D-dimer thresholds in those aged 50 and above. Findings revealed that only 14.6% of CTPA scans confirmed PE. Notably, 46.93% of patients under 50 with a PERC score of 0 underwent unnecessary imaging, and 13 patients aged 50 and above with normal age-adjusted D-dimer levels had CTPA, all yielding negative results. These findings indicate a significant overuse of CTPA in low-risk patients. Improving adherence to risk stratification tools through clinician education, decision-support tools, and increased awareness could reduce unnecessary imaging, minimize radiation exposure, and optimize healthcare resource utilization.
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